C-reactive protein, Epstein-Barr virus, and cortisol trajectories in refugee and non-refugee youth: Links with stress, mental health, and cognitive function during a randomized controlled trial.

Brain, Behavior, and Immunity
Catherine Panter-BrickKristin Hadfield

Abstract

Experiencing childhood adversity has been associated with significant changes in inflammation, cell-mediated immunocompetence, and cortisol secretion. Relatively few studies have examined, longitudinally, alterations to inflammatory processes during adolescence, especially outside Western contexts; none have evaluated biomarker trajectories for at-risk youth in response to a structured behavioral intervention. We conducted a randomized controlled trial evaluating the efficacy of a humanitarian intervention targeting stress-alleviation, with 12-18 year-old Syrian refugees (n = 446) and Jordanian non-refugees (n = 371) living side-by-side in war-affected communities in Jordan. We measured C-reactive protein (CRP), Epstein-Barr virus antibodies (EBV), and hair cortisol concentration (HCC) at three timepoints (pre/post intervention and 11 month follow-up), and assessed three main outcomes (psychosocial stress, mental health, and cognitive function). Using growth mixture models, regressions, and growth curve models, we identified three distinct trajectories for CRP, two for EBV, and three for HCC, and examined their associations with age, gender, BMI, poverty, and trauma. We found associations with BMI for CRP, refugee status for EB...Continue Reading

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Citations

Jun 17, 2020·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Jiying LingLorraine B Robbins
Aug 28, 2021·Frontiers in Immunology·Ying-Yi LuanYong-Ming Yao
Nov 24, 2021·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Eline van der ValkElisabeth van Rossum

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Methods Mentioned

BETA
ELISA

Clinical Trials Mentioned

NCT03012451

Software Mentioned

MPlus
RACER

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