C-reactive protein evolution in obstructive sleep apnoea patients under CPAP therapy

European Journal of Clinical Investigation
Sophia E SchizaNikolaos M Siafakas

Abstract

C-reactive protein (CRP) is recognized as a potential factor implicated in atherogenesis and associated cardiovascular morbidity. The aim of our study was to assess the CRP evolution during 1-year follow-up period in obstructive sleep apnoea (OSA) patients under CPAP treatment. Five hundred and twenty-eight patients with newly diagnosed moderate to severe OSA were included. CRP was assessed before CPAP initiation and at the 3rd, 6th and 12th month of the follow-up period. Patients were divided into good and poor CPAP compliance groups. A significant reduction in CRP levels was observed after CPAP therapy (0·74±0·62mgdL(-1) vs. 0·31±0·29mgdL(-1) , P<0·001) in the whole patient group. The evolution of CRP values showed a gradual decrease at 3months with a steep decline at 6months, reaching a plateau after this time point. When the patients were divided into those with good and poor compliance with CPAP therapy, the above CRP evolution pattern was observed only in the former group. Good CPAP compliance results in a significant CRP reduction. To achieve the best positive impact on cardiovascular morbidity and mortality, a time period of at least 6months of CPAP use is required.

References

Jun 1, 1990·The American Journal of Clinical Nutrition·R B MazessJ Hanson
May 11, 2000·The New England Journal of Medicine·P E PeppardJ Skatrud
Feb 24, 2001·American Journal of Respiratory and Critical Care Medicine·E ShaharJ M Samet
Mar 6, 2002·Circulation·Peter LibbyAttilio Maseri
Mar 13, 2002·Circulation·Johann W AuerBernd Eber
May 30, 2002·Circulation·Abu S M ShamsuzzamanVirend K Somers
Jun 19, 2002·Trends in Cardiovascular Medicine·Burkhard LudewigHans Hengartner
Jun 24, 2004·Sleep & Breathing = Schlaf & Atmung·Venetia TsaraPandora Christaki
Feb 3, 2005·Sleep·Christian GuilleminaultMaurice M Ohayon
Aug 2, 2006·The European Respiratory Journal·K MinoguchiM Adachi
Jul 13, 2007·Chest·Susheel P PatilPhilip L Smith
Feb 6, 2008·Proceedings of the American Thoracic Society·Terri E Weaver, Ronald R Grunstein
Jul 2, 2009·The European Respiratory Journal·P LévyJ Eckel

❮ Previous
Next ❯

Citations

Sep 2, 2011·Sleep & Breathing = Schlaf & Atmung·Charalampos MermigkisSophia E Schiza
Feb 8, 2011·Obesity Surgery·Maria PallayovaAlan R Schwartz
Dec 1, 2012·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Athanasios PanoutsopoulosIoannis Nikolopoulos
Sep 3, 2013·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Qi-Chang LinShao-Yong Gao
Aug 13, 2013·Pulmonary Medicine·Carlos ZamarrónRodolfo Alvarez-Sala
May 23, 2014·Sleep & Breathing = Schlaf & Atmung·Banu SalepciEgehan Salepci
Jun 14, 2014·Sleep & Breathing = Schlaf & Atmung·Sophia E SchizaIzolde Bouloukaki
May 21, 2015·World Journal of Experimental Medicine·Izolde BouloukakiSophia E Schiza
Jul 6, 2014·The European Respiratory Journal·Izolde BouloukakiSophia E Schiza

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.