C-reactive protein expression is up-regulated in apical lesions of endodontic origin in association with interleukin-6

Journal of Endodontics
Mauricio GarridoMarcela Hernández

Abstract

C-reactive protein (CRP) is the prototype component of acute-phase proteins induced ultimately by interleukin (IL)-6 in the liver, but it is unknown whether periradicular tissues locally express CRP. The present study aimed to identify whether CRP messenger RNA synthesis occurs in situ within apical lesions of endodontic origin (ALEOs) and healthy periodontal ligament and its association with IL-6 and to determine their protein levels and tissue localization. Patients with asymptomatic apical periodontitis and healthy volunteers presenting at the School of Dentistry, University of Chile, Santiago, Chile, were enrolled. ALEOs and healthy teeth were obtained and processed for either immunohistochemistry and double immunofluorescence to assess IL-6 and CRP tissue localization, whereas healthy periodontal ligaments were processed as controls for real-time reverse-transcription polymerase chain reaction for their RNA expression levels and multiplex assay to determine their protein levels. Statistic analysis was performed using the unpaired t test or Mann-Whitney test according to data distribution and Pearson correlation. IL-6 and CRP were synthesized in ALEOs, whereas their RNA expression and protein levels were significantly highe...Continue Reading

References

Jul 18, 2001·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·G T HuangN Chugal
May 15, 2007·Mediators of Inflammation·Ivana Brekalo PrsoIvana Miletić Karlović
Sep 4, 2008·Journal of Periodontology·Paul M Ridker, Josh D Silvertown
Jul 22, 2009·Cardiovascular Research·Sridevi DevarajIshwarlal Jialal
Nov 26, 2009·Journal of Endodontics·James L GutmannRichard E Walton
Dec 10, 2009·Journal of Clinical Periodontology·Tracy R FitzsimmonsGary D Slade
May 11, 2010·Journal of Periodontology·Ahmed R El-AwadyCarol A Lapp
Jul 14, 2010·Journal of Clinical Periodontology·Emma MegsonP Mark Bartold
Jul 30, 2010·Journal of Clinical Periodontology·Qian Lu, Lijian Jin
May 7, 2011·Journal of Oral Microbiology·Dana T GravesGustavo P Garlet
Sep 18, 2013·Journal of Endodontics·Maximiliano Schünke GomesMark A Reynolds
Nov 15, 2013·International Endodontic Journal·M M AzumaL T A Cintra
Jan 28, 2014·Journal of Endodontics·Tatiana Hassin Rodrigues CostaAiza Leal de Almeida

❮ Previous
Next ❯

Citations

Jun 17, 2016·Contemporary Clinical Dentistry·Medhini Madhavan MenonJanardhanan Sureshkumar
Dec 27, 2018·Acta Odontologica Scandinavica·Paulo Henrique Braz-SilvaPeter Jonasson
Mar 7, 2017·Clinical Oral Investigations·M Salinas-MuñozM Hernández
Jan 2, 2020·Dentistry Journal·Giuseppe Lo GiudiceGioacchino Calapai
May 24, 2020·Clinical Oral Investigations·Pablo VelosoMarcela Hernández
Oct 27, 2018·Brazilian Oral Research·Brenda Paula Figueiredo de Almeida Gomes, Daniel Rodrigo Herrera
Jan 8, 2021·Clinical Oral Investigations·C SchweitzerMarcela Hernández Rios

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.