PMID: 11310937Apr 20, 2001Paper

C-reactive protein, fibrinogen, interleukin-6 and tumour necrosis factor-alpha in the prognostic classification of unstable angina pectoris

Annals of Medicine
H KoukkunenK Pyörälä

Abstract

Inflammatory process has been found to play an important role in the pathogenesis of coronary heart disease (CHD) and in the prognosis of CHD patients. AIM. The aim of this study was to investigate the prognostic value of C-reactive protein (CRP), fibrinogen, interleukin (IL)-6 and tumour necrosis factor-alpha (TNF-alpha) in patients with unstable angina pectoris (UAP), including factor analysis to assess their joint effects. The study comprised 263 consecutive patients (159 men, 104 women; median age 68 years) with UAP. Blood samples for the acute-phase protein and cytokine determinations were drawn on admission. Coronary mortality during the median follow-up time of 17 months was 6-fold higher in the highest tertile for CRP and IL-6 and 3.5-fold higher in the highest tertile for fibrinogen and TNF-alpha than in the respective combined lower tertiles. Factor analysis produced two underlying factors, ie the 'inflammation' factor, including CRP, fibrinogen and IL-6, and the 'injury' factor, including troponin T, creatine kinase MB mass and TNF-alpha. In Cox models, both of these factors were independent predictors of the risk of coronary death and major coronary events (coronary death or nonfatal myocardial infarction). Elevated...Continue Reading

References

Oct 1, 1990·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·D L Amrani
Aug 18, 1994·The New England Journal of Medicine·G LiuzzoA Maseri
Aug 18, 1994·The New England Journal of Medicine·R W Alexander
May 1, 1996·American Journal of Clinical Pathology·M C Cohen, S Cohen
Jan 17, 1996·Annals of the New York Academy of Sciences·J S RichardsonU Kumar
Mar 15, 1996·Circulation·G A HaywoodM B Fowler
Sep 1, 1996·Circulation·L M BiasucciA Maseri
Apr 3, 1997·The New England Journal of Medicine·P M RidkerC H Hennekens
Jan 1, 1997·Frontiers in Bioscience : a Journal and Virtual Library·C A Feghali, T M Wright
Nov 14, 1997·The American Journal of Cardiology·L OltronaA Pezzano
Aug 1, 1997·Annals of Medicine·K J Pulkki
Jan 14, 1999·The New England Journal of Medicine·R Ross
Feb 11, 1999·The New England Journal of Medicine·C Gabay, I Kushner
Nov 11, 1999·Circulation·E R FerreirósO O Bazzino
Mar 23, 2000·Journal of Thrombosis and Thrombolysis·A D SimonL E Rabbani
Apr 13, 2000·Journal of Internal Medicine·P Libby
Jun 14, 2000·Annals of Medicine·T W Du Clos

❮ Previous
Next ❯

Citations

Dec 27, 2008·Bulletin of Experimental Biology and Medicine·Yu I RaginoYu P Nikitin
Feb 2, 2002·Current Atherosclerosis Reports·John A Farmer, Guillermo Torre-Amione
Aug 29, 2013·Biological Trace Element Research·Iulia Daria Scorei, Romulus Ion Scorei
May 24, 2003·Clinica Chimica Acta; International Journal of Clinical Chemistry·Shui-Ping ZhaoQuan-Zhong Li
Dec 9, 2003·International Journal of Cardiology·Vicent BodíFrancisco J Chorro
Jan 27, 2005·Rejuvenation Research·Tracey Phillips, Christiaan Leeuwenburgh
Jan 1, 2010·Rejuvenation Research·Karen Bandeen-RocheLuigi Ferrucci
Jan 30, 2010·American Journal of Epidemiology·Nicolas RodondiUNKNOWN Health, Aging, and Body Composition Study
Jun 3, 2011·European Heart Journal·Andrew SteptoeJuan Carlos Kaski
Feb 21, 2009·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Fang-Chi HsuUNKNOWN Health ABC Study
Jul 10, 2002·Current Opinion in Nephrology and Hypertension·Mariusz L KielarChristopher Y Lu
Apr 27, 2005·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Barbara J NicklasMarco Pahor
Oct 24, 2002·Clinical Chemistry and Laboratory Medicine : CCLM·Victor Sánchez-MargaletRaimundo Goberna
Dec 6, 2003·Journal of Endovascular Therapy : an Official Journal of the International Society of Endovascular Specialists·Vibeke VidemHans Olav Myhre
Jan 5, 2002·Scandinavian Cardiovascular Journal : SCJ·H KoukkunenK Pyörälä
Oct 30, 2004·Scandinavian Cardiovascular Journal : SCJ·Martin WesterbergAnders Jeppsson
Feb 9, 2016·Canadian Journal of Physiology and Pharmacology·Amr M Abbas, Hussein F Sakr
Dec 18, 2009·Kidney International·Daniela V BarretoUNKNOWN European Uremic Toxin Work Group (EUTox)
Jun 22, 2016·Annals of Behavioral Medicine : a Publication of the Society of Behavioral Medicine·Natalie L TuckNathan S Consedine
May 18, 2016·Clinical Biochemistry·Wesley Elon FlemingPaula C Southwick
Sep 30, 2008·Psychoneuroendocrinology·Alexander HaenselJoel E Dimsdale
Nov 6, 2007·Brain, Behavior, and Immunity·Roland von KänelJoel E Dimsdale

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.