C-reactive protein gene polymorphism predicts the risk of thromboembolic stroke in patients with atrial fibrillation: a more than 10-year prospective follow-up study

Journal of Thrombosis and Haemostasis : JTH
S-N ChangC-T Tsai

Abstract

Essentials We studied the C-reactive protein (CRP) gene on stroke risk in atrial fibrillation (AF) patients. 725 patients with CRP triallelic polymorphism genotype were followed-up for more than 10 years. Patients with the A-390/T-390 allele of the CRP gene were more likely to get ischemic stroke. The triallelic polymorphism of the CRP is related to ischemic stroke in AF patients. Background Little evidence is available regarding the impact of genetic polymorphisms on the risk of thromboembolic stroke in patients with atrial fibrillation (AF). An increasing body of evidence is demonstrating that inflammatory responses play an important role in the pathophysiology of AF. Objectives To investigate the effect of genetic polymorphisms of the C-reactive protein (CRP) gene on the incidence of thromboembolic stroke in patients with AF. Methods A total of 725 AF patients were longitudinally followed up for > 10 years; this is the largest and longest AF follow-up cohort with genetic data. CRP promoter triallelic polymorphisms (C-390A and C-390T) were genotyped, and CRP levels were divided into four quartiles. Results Patients with higher CRP levels were more likely to develop thromboembolic stroke than those with lower CRP levels (P<0.0...Continue Reading

References

Nov 19, 2003·Circulation·Ronnier J AvilesMina K Chung
Jun 3, 2004·Journal of the American College of Cardiology·Dwayne S G ConwayGregory Y H Lip
Nov 10, 2005·European Heart Journal·Christopher J BoosGregory Y H Lip
Apr 17, 2007·Journal of the American College of Cardiology·Tong LiuPanagiotis Korantzopoulos
Nov 13, 2007·Lancet·Michele Coceani
Nov 21, 2007·Journal of the American College of Cardiology·Tim T IssacNasser M Lakkis
May 3, 2008·Journal of the American College of Cardiology·Joseph G AkarDavid J Wilber
Jul 29, 2008·International Journal of Cardiology·Dimitris TousoulisChristodoulos Stefanadis
May 28, 2011·Revista española de cardiología·Juan Carlos Kaski, Antonio L Arrebola-Moreno
Dec 1, 2012·Journal of the American College of Cardiology·Yutao GuoStavros Apostolakis
Oct 22, 2013·The American Journal of Medicine·Joellyn M AbrahamSylvia Wassertheil-Smoller
May 23, 2015·Journal of the American College of Cardiology·Benjamin J HirshJonathan L Halperin
Jun 4, 2016·PloS One·Ryu MatsuoUNKNOWN Fukuoka Stroke Registry Investigators
Jun 30, 2016·International Journal of Environmental Research and Public Health·He-Hong GengPei-Xi Wang

❮ Previous
Next ❯

Citations

Mar 13, 2019·Journal of Clinical Medicine·Chia-Shan HsiehChia-Ti Tsai
May 21, 2021·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Dimpi PatelJawed Fareed

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Atrial Filbrillation

Atrial fibrillation refers to the abnormal heart rhythm characterized by rapid and irregular beating of the atria. Here is the latest research.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Related Papers

Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology
Chang Hee KwonKi-Chul Sung
© 2022 Meta ULC. All rights reserved