C-Reactive protein in adults with chronic spinal cord injury: increased chronic inflammation in tetraplegia vs paraplegia

Spinal Cord
A E GibsonSHAPE-SCI Research Group

Abstract

Cross-sectional. In community-dwelling adults with chronic spinal cord injury (SCI), to (1) quantify C-reactive protein (CRP), a marker of inflammation and cardiovascular disease (CVD) risk; (2) determine factors associated with CRP. Hamilton, Ontario, Canada. We examined CVD risk factors in 69 participants. Measurements included length, weight, waist circumference, blood pressure, percent fat mass (bioelectrical impedance analysis) and fasting blood parameters (high-sensitivity CRP, lipids, insulin, glucose, insulin resistance by homeostasis model assessment (HOMA)). Mean CRP of the group was 3.37+/-2.86 mg-l(-1), consistent with the American Heart Association (AHA) definition of high risk of CVD. CRP was 74% higher in persons with tetraplegia (4.31+/-2.97) than those with paraplegia (2.47+/-2.47 mg l(-1), P=0.002), consistent with high CVD risk. Participants with high CRP (3.1-9.9 mg l(-1)) had greater waist circumference, BMI, percent fat mass and HOMA values than those with lower CRP (< or =3.0 mg l(-1), all P<0.05). LogCRP was independently correlated with waist circumference (r=0.612), logTriglycerides (r=0.342), logInsulin (r=0.309) and logHOMA (r=0.316, all P<0.05). Only level of lesion and waist circumference remained ...Continue Reading

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Citations

Sep 22, 2009·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Andrea C BuchholzDalton L Wolfe
Aug 29, 2012·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Andrea C BuchholzDalton L Wolfe
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Jul 30, 2014·Archives of Physical Medicine and Rehabilitation·Céline R Neefkes-ZonneveldThomas W Janssen
Jul 9, 2014·The Journal of Spinal Cord Medicine·Ashraf S GorgeyDavid R Gater
Dec 6, 2014·Topics in Spinal Cord Injury Rehabilitation·James S KrauseSookyoung Park
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Nov 5, 2014·Spinal Cord·D J Allison, D S Ditor
Aug 23, 2017·PM & R : the Journal of Injury, Function, and Rehabilitation·Shannon D SullivanSuzanne Groah
Jun 11, 2019·The Journal of Spinal Cord Medicine·Mark S NashAllen J Taylor
Jan 18, 2018·Topics in Spinal Cord Injury Rehabilitation·Crystal M NollerMark S Nash
Jan 18, 2018·Topics in Spinal Cord Injury Rehabilitation·Gregory Bigford, Mark S Nash
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Apr 6, 2021·Topics in Spinal Cord Injury Rehabilitation·David R GaterEduard Tiozzo
Apr 6, 2021·Topics in Spinal Cord Injury Rehabilitation·Gary J FarkasDavid R Gater

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