C-reactive protein is a more sensitive and specific marker for diagnosing bacterial infections in systemic lupus erythematosus compared to S100A8/A9 and procalcitonin

The Journal of Rheumatology
Hyoun-Ah KimChang-Hee Suh

Abstract

C-reactive protein (CRP), S100A8/A9, and procalcitonin have been suggested as markers of infection in patients with systemic lupus erythematosus (SLE). We investigated the clinical significance of these factors for indication of infection in SLE. Blood samples were prospectively collected from 34 patients with SLE who had bacterial infections and 39 patients with SLE who had disease flares and no evidence of infection. A second set of serum samples was collected after the infections or flares were resolved. CRP levels of SLE patients with infections were higher than those with flares [5.9 mg/dl (IQR 2.42, 10.53) vs 0.06 mg/dl (IQR 0.03, 0.15), p < 0.001] and decreased after the infection was resolved. S100A8/A9 and procalcitonin levels of SLE patients with infection were also higher [4.69 μg/ml (IQR 2.25, 12.07) vs 1.07 (IQR 0.49, 3.05) (p < 0.001) and 0 ng/ml (IQR 0-0.38) vs 0 (0-0) (p < 0.001), respectively]; these levels were also reduced once the infection disappeared. In the receiver-operating characteristics analysis of CRP, S100A8/A9, and procalcitonin, the area under the curve was 0.966 (95% CI 0.925-1.007), 0.732 (95% CI 0.61-0.854), and 0.667 (95% CI 0.534-0.799), respectively. CRP indicated the presence of an infecti...Continue Reading

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Citations

Oct 9, 2013·Expert Opinion on Medical Diagnostics·Ju-Yang JungChang-Hee Suh
Jul 17, 2013·Asia-Pacific Psychiatry : Official Journal of the Pacific Rim College of Psychiatrists·Chin-Chuen LinTiao-Lai Huang
Jun 7, 2013·The British Journal of Dermatology·G B E Jemec
Apr 18, 2015·International Journal of Rheumatic Diseases·Ju-Yang Jung, Chang-Hee Suh
May 20, 2005·Pathology, Research and Practice·Solange RomagnoliSilvano Bosari
Oct 19, 2016·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Jing GaoLi-Hua Xing
May 12, 2017·The Korean Journal of Internal Medicine·Ju-Yang Jung, Chang-Hee Suh
Jun 19, 2012·The Journal of Rheumatology·Marco Ulises Martínez-MartínezCarlos Abud-Mendoza
Jul 16, 2014·Current Opinion in Rheumatology·Sandra G PasotoEloisa Bonfa
Jun 5, 2014·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·Ju-Yang JungChang-Hee Suh
Jul 9, 2017·Clinical Rheumatology·Lin QiaoFengchun Zhang
May 18, 2013·The Korean Journal of Internal Medicine·Hyuck Lee

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