C-Reactive Protein Is Elevated Only in High Creatine Kinase Responders to Muscle Damaging Exercise

Frontiers in Physiology
A W IsaacsK H Myburgh

Abstract

The purpose of this study was to investigate if exertional rhabdomyolysis induced by an acute bout of plyometric exercise in untrained individuals was associated with histological characteristics of skeletal muscle, creatine kinase (CK) polymorphism or secondary damage. Twenty-six healthy male untrained individuals completed a bout of plyometric exercise (10 sets of 10 maximal squat jumps, with each standardized to achieve at least 95% of individual maximal jump height). Blood samples were taken, and perceived pain was scored immediately before the exercise intervention and 6 h, 1, 2, and 3 days post-intervention. Muscle biopsies were collected 9 or 4 days before (baseline) and 3 days after plyometric jumps. Subjects were divided into two groups, high (n = 10) and low responders (n = 16), based on a cut-off limit for exertional rhabdomyolysis of peak CK activity ≥ 1000 U/L in any post-exercise blood sample. Perceived pain was more severe assessed in squat than standing position. Low responders perceived more pain at 6 h and 1 day, while high responders perceived more pain than low responders on days three and four after exercise; structural (dystrophin staining) and ultra-structural (transmission electron microscopy) analysis o...Continue Reading

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Citations

Aug 18, 2020·Scandinavian Journal of Medicine & Science in Sports·Svein Ivar Bekkelund
Jun 12, 2020·Journal of Applied Physiology·Stuart M C LeeMichael B Stenger
Apr 27, 2021·International Journal of Sports Medicine·Carlos Rodriguez-LopezLuis M Alegre

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Methods Mentioned

BETA
biopsies
biopsy
Enzyme-Linked
ELISA
PCR
electrophoresis

Software Mentioned

ClustalW
SPSS
Sequencing Analysis
BioEdit
PASW

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