C-reactive protein levels in subjects with Prader-Willi syndrome and obesity.

Genetics in Medicine : Official Journal of the American College of Medical Genetics
Merlin G ButlerUttam Garg

Abstract

Prader-Willi syndrome is characterized by infantile hypotonia, feeding difficulties, hypogonadism, small hands and feet, mental deficiency, behavioral problems, and hyperphagia leading to obesity in early childhood. To date there have been no studies examining the associated risk of cardiovascular disease related to obesity in Prader-Willi syndrome, nor of circulating biomarkers such as C-reactive protein known to be predictive of cardiovascular disease. Therefore, we have measured the levels of C-reactive protein in a descriptive study of a cohort of Prader-Willi syndrome and comparison subjects. An immunoassay was used to quantify C-reactive protein in plasma samples from subjects with Prader-Willi syndrome and obesity and compared to anthropometric and body composition data. The mean circulating C-reactive protein concentration for 28 subjects with Prader-Willi syndrome (13 females, 15 males; mean age 24.6 +/- 11.6 years; mean body mass index 35.9 +/- 11.9) was 10.3 +/- 8.8 mg/L. The mean C-reactive protein concentration for 22 nonsyndromic obese subjects (16 females, 6 males; mean age 32.3 +/- 12.2 years; mean body mass index 36.6 +/- 10.7) was 8.8 +/- 10.9 mg/L. The reported mean value for C-reactive protein was 2.6 +/- 3....Continue Reading

References

Feb 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·A P OsmandE Shelton
Mar 1, 1990·American Journal of Medical Genetics·M G Butler
Mar 1, 1990·Postgraduate Medical Journal·S R PageJ S Jenkins
Dec 1, 1987·American Journal of Medical Genetics·A S Lamb, W M Johnson
Jan 1, 1984·Scandinavian Journal of Rheumatology·J S DixonV Wright
Aug 1, 1994·Baillière's Clinical Rheumatology·M A van Leeuwen, M H van Rijswijk
May 1, 1993·Clinical Pediatrics·R H Ruvalcaba, V A Holm
Apr 3, 1997·The New England Journal of Medicine·P M RidkerC H Hennekens
Dec 11, 1999·JAMA : the Journal of the American Medical Association·M VisserT B Harris
Feb 17, 2001·American Journal of Medical Genetics·S B CassidyC A Williams
Feb 6, 2002·Circulation·André TchernofEric T Poehlman
Aug 21, 2003·JAMA : the Journal of the American Medical Association·Daniel G Hackam, Sonia S Anand
Apr 9, 2004·The New England Journal of Medicine·John DaneshVilmundur Gudnason
May 18, 2005·American Journal of Human Genetics·Christopher S CarlsonAlexander P Reiner
Jul 26, 2005·Expert Reviews in Molecular Medicine·Douglas C Bittel, Merlin G Butler
Oct 19, 2005·International Journal of Obesity : Journal of the International Association for the Study of Obesity·L KennedyM G Butler
Sep 30, 1930·The Journal of Experimental Medicine·W S Tillett, T Francis

❮ Previous
Next ❯

Citations

Jun 6, 2009·Intellectual and Developmental Disabilities·Kathleen HumphriesTom Seekins
Mar 26, 2008·Journal of Endocrinological Investigation·A CaixàsJ M González-Clemente
Apr 18, 2007·Clinical Endocrinology·Sanjay PatelDavid S Celermajer
Dec 12, 2012·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·G GrugniP Brambilla
Jan 11, 2016·Clinical Anatomy : Official Journal of the American Association of Clinical Anatomists & the British Association of Clinical Anatomists·Bradley J Hurren, Natasha A M S Flack
Feb 19, 2015·American Journal of Medical Genetics. Part a·Merlin G ButlerAnn M Manzardo
Jul 6, 2018·Journal of Pediatric Endocrinology & Metabolism : JPEM·Kelsey L McAlisterDaniela A Rubin
Jan 27, 2018·International Journal of Pediatric Endocrinology·I Caroline van NieuwpoortMadeleine L Drent
May 7, 2010·The Journal of Clinical Endocrinology and Metabolism·Alexander ViardotLesley V Campbell
Jan 30, 2014·The Journal of Clinical Endocrinology and Metabolism·Claudio L LafortunaGraziano Grugni
Aug 26, 2014·Journal of Deaf Studies and Deaf Education·David P CorinaKearnan Welch

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.