C-reactive protein trajectory to predict colorectal anastomotic leak: PREDICT Study.

The British Journal of Surgery
B D StephensenPREDICT Study Group collaborators

Abstract

Anastomotic leak is a common complication after colorectal surgery, associated with increased morbidity and mortality, and poorer long-term survival after oncological resections. Early diagnosis improves short-term outcomes, and may translate into reduced cancer recurrence. Multiple studies have attempted to identify biomarkers to enable earlier diagnosis of anastomotic leak. One study demonstrated that the trajectory of C-reactive protein (CRP) levels was highly predictive of anastomotic leak requiring intervention, with an area under the curve of 0·961. The aim of the present study was to validate this finding externally. This was a prospective international multicentre observational study of adults undergoing elective colorectal resection with an anastomosis. CRP levels were measured before operation and for 5 days afterwards, or until day of discharge if earlier than this. The primary outcome was anastomotic leak requiring operative or radiological intervention. Between March 2017 and July 2018, 933 patients were recruited from 20 hospitals across Australia, New Zealand, England and Scotland. Some 833 patients had complete CRP data and were included in the primary analysis, of whom 41 (4·9 per cent) developed an anastomotic...Continue Reading

References

Mar 25, 2005·Diseases of the Colon and Rectum·Graham BranaganUNKNOWN Wessex Colorectal Cancer Audit Working Group
Jan 25, 2007·Annals of Surgery·Neil HymanPeter A Cataldo
Dec 12, 2007·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·A A KhanN J McC Mortensen
Feb 20, 2008·World Journal of Surgery·R PhitayakornUNKNOWN International Anastomotic Leak Study Group
Jan 30, 2009·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·J FryeO F Dent
May 22, 2013·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Benjamin D ShoganKonstantin Umanskiy

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Citations

Dec 4, 2020·World Journal of Gastroenterology : WJG·Fang-Ze WeiQian Liu
Jan 21, 2021·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·Andrew S MillerDanette Wright
Jan 12, 2021·Scandinavian Journal of Gastroenterology·Waqas FarooquiJan Henrik Storkholm
Mar 13, 2021·The British Journal of Surgery·Cheng-Hao TsengChong-Chi Chiu
Nov 4, 2020·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Antonio V SterpettiPaolo Sapienza
May 16, 2021·The British Journal of Surgery·Bree D StephensenUNKNOWN PREDICT Study Group collaborators
Jun 4, 2021·International Journal of Colorectal Disease·Carmen Cagigas FernándezMarcos Gomez Ruiz
Mar 14, 2021·The British Journal of Surgery·Joost D J PlateDjamila Boerma
Mar 14, 2021·The British Journal of Surgery·Bree D StephensenUNKNOWN PREDICT Study Group collaborators
Oct 28, 2021·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·Vincent T HoekUNKNOWN APPEAL II collaborators

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