C-terminal agrin fragment--a new fast biomarker for kidney function in renal transplant recipients

American Journal of Nephrology
Dominik SteublMarcel Roos

Abstract

The C-terminal agrin fragment (CAF) is a cleavage product of agrin, the major proteoglycan of the glomerular basement membrane. This article studies if CAF could serve as a biomarker for renal function in renal transplant recipients. We measured serum CAF and creatinine concentrations and calculated estimated glomerular filtration rate (eGFR) (MDRD) in 96 healthy individuals and in 110 end-stage renal disease patients undergoing kidney transplantation before and after transplantation. Correlation between CAF and creatinine concentrations/eGFR was calculated as within-patient (cWP) and between-patient correlations (cBP). Moreover, we evaluated the association of CAF with delayed graft function (DGF). The diagnostic value of CAF for early detection of DGF compared to creatinine was evaluated by receiver operating characteristics (ROC) analysis. CAF concentrations strongly correlated with creatinine (r = 0.86 (cWP), r = 0.74 (cBP)) and eGFR (MDRD) (r = 0.86 (cWP), r = 0.77 (cBP)). Pre-transplant (pre-Tx) CAF concentrations were 19-fold higher than in healthy individuals (1,115.0 (258.4-3,990.0) vs. 56.6 (20.0-109.5) pM). After transplantation, CAF decreased significantly faster than creatinine (postoperative days 1-3 (POD 1-3): 56...Continue Reading

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Citations

Jun 8, 2014·Translational Research : the Journal of Laboratory and Clinical Medicine·Dominik SteublMarcel Roos
Dec 30, 2014·BMC Medical Genomics·Hannes NeuwirtMichael Rudnicki
Jun 19, 2015·Clinical Chemistry and Laboratory Medicine : CCLM·Dominik SteublMarcel Roos
Apr 12, 2016·Journal of Cachexia, Sarcopenia and Muscle·Nadja ScherbakovWolfram Doehner
Oct 30, 2014·International Urology and Nephrology·Dominik SteublMarcel Roos
Oct 30, 2016·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Dominik SteublJürgen Scherberich
Feb 16, 2016·Clinical Chemistry and Laboratory Medicine : CCLM·Dominik SteublLutz Renders
Apr 1, 2020·Biomolecules·Elena Rodríguez-SánchezGema Ruiz-Hurtado
Mar 15, 2015·American Journal of Physiology. Gastrointestinal and Liver Physiology·Morten A KarsdalDetlef Schuppan
Oct 21, 2015·The Journal of Nutrition, Health & Aging·I BondocUNKNOWN Life Study Investigators

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