C-type lectin-like domain and fibronectin-like type II domain of phospholipase A(2) receptor 1 modulate binding and migratory responses to collagen

FEBS Letters
Soichiro TakahashiKiyotaka Kugiyama

Abstract

Phospholipase A2 receptor 1 (PLA2R) mediates collagen-dependent migration. The mechanisms by which PLA2R interacts with collagen remain unclear. We produced HEK293 cells expressing full-length wild-type PLA2R or a truncated PLA2R that lacks fibronectin-like type II (FNII) domains or several regions of C-type lectin-like domain (CTLD). We show that the CTLD1-2 as well as the FNII domain of PLA2R are responsible for binding to collagen and for collagen-dependent migration. Thus, multiple regions and domains of the extracellular portion of PLA2R participate in the responses to collagen. These data suggest a potentially new mechanism for PLA2R-mediated biological response beyond that of a receptor for secretory PLA2.

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Citations

Sep 1, 2015·International Journal of Oncology·Maria C MelanderNiels Behrendt
Jan 10, 2017·Kidney International·Daniel C Cattran, Paul E Brenchley
May 24, 2018·American Journal of Physiology. Cell Physiology·Kazunori WatanabeKiyotaka Kugiyama
Jul 5, 2017·Journal of the American Society of Nephrology : JASN·Laurence H Beck
Oct 18, 2019·Annual Review of Pathology·Pierre Ronco, Hanna Debiec
Feb 23, 2020·Journal of Immunology Research·Maël LatebBarbara Seitz-Polski
Feb 6, 2020·Inflammation·Hiroki KishiKiyotaka Kugiyama
Aug 2, 2017·Scientific Reports·Maryline FresquetPaul E Brenchley
Apr 8, 2021·Cell and Tissue Research·Nicola M TomasElion Hoxha

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