C-Type Lectin-Like Receptors: Head or Tail in Cell Death Immunity.

Frontiers in Immunology
Marion DrouinElise Chiffoleau

Abstract

C-type lectin-like receptors (CLRs) represent a family of transmembrane pattern recognition receptors, expressed primarily by myeloid cells. They recognize not only pathogen moieties for host defense, but also modified self-antigens such as damage-associated molecular patterns released from dead cells. Upon ligation, CLR signaling leads to the production of inflammatory mediators to shape amplitude, duration and outcome of the immune response. Thus, following excessive injury, dysregulation of these receptors leads to the development of inflammatory diseases. Herein, we will focus on four CLRs of the "Dectin family," shown to decode the immunogenicity of cell death. CLEC9A on dendritic cells links F-actin exposed by dying cells to favor cross-presentation of dead-cell associated antigens to CD8+ T cells. Nevertheless, CLEC9A exerts also feedback mechanisms to temper neutrophil recruitment and prevent additional tissue damage. MINCLE expressed by macrophages binds nuclear SAP130 released by necrotic cells to potentiate pro-inflammatory responses. However, the consequent inflammation can exacerbate pathogenesis of inflammatory diseases. Moreover, in a tumor microenvironment, MINCLE induces macrophage-induced immune suppression an...Continue Reading

References

Jun 1, 1973·Teratology·J U Schweichel, H J Merker
Jan 1, 1994·Annual Review of Immunology·P Matzinger
Aug 5, 1998·Proceedings of the National Academy of Sciences of the United States of America·K OkaT Masaki
Oct 6, 1999·Current Opinion in Structural Biology·K Drickamer
Jan 5, 2000·Proceedings of the National Academy of Sciences of the United States of America·M KakutaniT Sawamura
Mar 11, 2000·Arteriosclerosis, Thrombosis, and Vascular Biology·T MuraseT Kita
Apr 6, 2000·American Journal of Physiology. Heart and Circulatory Physiology·G Draude, R L Lorenz
Apr 6, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·T ShimaokaS Yonehara
Jun 21, 2001·Biochemical and Biophysical Research Communications·H MorawietzJ Holtz
Oct 2, 2002·Immunity·Yves DelnestePascale Jeannin
Mar 27, 2003·Biochemical Society Symposium·Kurt Drickamer, Andrew J Fadden
Feb 1, 1965·Journal of Insect Physiology·R A LOCKSHIN, C M WILLIAMS
Mar 16, 2004·American Journal of Physiology. Heart and Circulatory Physiology·I V SmirnovaM S Goligorsky
Jun 3, 2004·Nature Reviews. Immunology·Seung-Yong Seong, Polly Matzinger
Oct 26, 2005·Cell Death and Differentiation·G KroemerUNKNOWN Nomenclature Committee on Cell Death
Feb 24, 2006·Proceedings of the National Academy of Sciences of the United States of America·Li HaoMasatoshi Nei
Jul 14, 2006·European Journal of Immunology·Andrew S J MarshallGordon D Brown
Nov 4, 2006·DNA Research : an International Journal for Rapid Publication of Reports on Genes and Genomes·Nobuo NakamuraTakahiro Ochi
Nov 18, 2006·Nature Immunology·Matthew J RobinsonCaetano Reis e Sousa
Sep 13, 2007·Diabetes·Katherine J StrisselMartin S Obin
Mar 20, 2008·European Journal of Immunology·Elwira PyzGordon D Brown
Apr 15, 2008·The Journal of Biological Chemistry·Cristal HuysamenGordon D Brown
Apr 15, 2008·Journal of Lipid Research·Kathryn C B TanRichard Bucala
May 24, 2008·The Journal of Clinical Investigation·David SanchoCaetano Reis e Sousa
Sep 9, 2008·Nature Immunology·Sho YamasakiTakashi Saito

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Citations

Aug 11, 2020·The Journal of Clinical Investigation·Darja AndreevAline Bozec
Sep 3, 2020·Cells·Maximiliano L CacicedoMatthias Bros
Jul 9, 2021·Analytical and Bioanalytical Chemistry·Asif ShajahanParastoo Azadi

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Methods Mentioned

BETA
dissection

Software Mentioned

MINCLE

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