C-type natriuretic peptide enhances mouse preantral follicle growth

Reproduction : the Official Journal of the Society for the Study of Fertility
Guangyin XiJianhui Tian

Abstract

Compared to ovarian antral follicle development, the mechanism underlying preantral follicle growth has not been well documented. Although C-type natriuretic peptide (CNP) involvement in preantral folliculogenesis has been explored, its detailed role has not been fully defined. Here, we used mouse preantral follicles and granulosa cells (GCs) as a model for investigating the dynamic expression of CNP and natriuretic peptide receptor 2 (NPR2) during preantral folliculogenesis, the regulatory role of oocyte-derived growth factors (ODGFs) in natriuretic peptide type C (Nppc) and Npr2 expression, and the effect of CNP on preantral GC viability. Both mRNA and protein levels of Nppc and Npr2 were gradually activated during preantral folliculogenesis. CNP supplementation in culture medium significantly promoted the growth of in vitro-cultured preantral follicles and enhanced the viability of cultured GCs in a follicle-stimulating hormone (FSH)-independent manner. Using adult and prepubertal mice as an in vivo model, CNP pre-treatment via intraperitoneal injection before conventional superovulation also had a beneficial effect on promoting the ovulation rate. Furthermore, ODGFs enhanced Nppc and Npr2 expression in the in vitro-cultured...Continue Reading

References

Sep 1, 1986·Journal of Reproduction and Fertility·D M HalpinM J Faddy
Mar 22, 2001·Proceedings of the National Academy of Sciences of the United States of America·H ChushoK Nakao
Dec 6, 2001·Reproduction : the Official Journal of the Society for the Study of Fertility·J J Eppig
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Feb 28, 2002·Proceedings of the National Academy of Sciences of the United States of America·John J EppigFrank L Pendola
Jun 23, 2006·Reproductive Biomedicine Online·Basak Balaban, Bulent Urman
May 9, 2007·Frontiers in Bioscience : a Journal and Virtual Library·Jesse CraigBenjamin K Tsang
Apr 17, 2008·Clinical Rheumatology·Ramazan YağciMeral Ekşioğlu
Oct 8, 2009·American Journal of Physiology. Endocrinology and Metabolism·Takei KakeKazuwa Nakao
Oct 31, 2009·Trends in Endocrinology and Metabolism : TEM·Alexandre BoyerDerek Boerboom
Dec 21, 2010·Asian Journal of Andrology·Dong-Hui HuangLing Zhang
Jan 21, 2011·Current Pharmaceutical Design·Natalie G LumsdenAdrian J Hobbs
Feb 8, 2011·Journal of cardiology·Toshio NishikimiKazuwa Nakao
Mar 1, 2012·Molecular and Cellular Endocrinology·Tomoko MiyoshiHirofumi Makino
May 19, 2012·Molecular Endocrinology·Yorino SatoAaron J W Hsueh
Jan 22, 2013·Zygote : the Biology of Gametes and Early Embryos·Yuki HiradateEimei Sato
Feb 15, 2013·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Yuan ChengAaron J W Hsueh
Feb 21, 2013·Reproductive Biology and Endocrinology : RB&E·Boqun XuJiayin Liu
Feb 20, 2015·The Journal of Clinical Endocrinology and Metabolism·Linlin JiangDongzi Yang
Oct 8, 2015·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Seyedeh Zeynab SadrRaha Favaedi
Dec 17, 2015·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Atefeh AbediniDerek Boerboom
Jun 1, 2017·Reproductive Biology and Endocrinology : RB&E·Yanhao ZhangGuoliang Xia

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Citations

Jan 20, 2021·Journal of Clinical Laboratory Analysis·Xiyan WangXiaoyan Pan
Jun 3, 2021·International Journal of Molecular Sciences·Yingjun ChenChangjiu He

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