PMID: 8594938Dec 1, 1995Paper

C1 neurons of neonatal rats: intrinsic beating properties and alpha 2-adrenergic receptors

The American Journal of Physiology
Y W LiP G Guyenet

Abstract

Tyrosine-hydroxylase-immunoreactive (TH-ir) neurons (C1 cells) of the rostral ventrolateral medulla (RVL) control sympathetic tone and may be inhibited by the hypotensive drug clonidine. The present study seeks to describe some of the intrinsic properties of bulbospinal C1 cells and to establish whether they have alpha 2-adrenergic inhibitory "autoreceptors." RVL bulbospinal cells (retrogradely labeled with microbeads) were recorded in thin slices from 3- to 7-day-old rats with patch electrodes containing Lucifer yellow. Forty-two of eighty-nine cells were recovered histologically, and 69% were TH-ir. The properties of TH-ir cells could not be distinguished from those of the other bulbospinal cells. Most cells were spontaneously active (0.5-5 spikes/s). Blockade of fast postsynaptic potentials with kynurenic acid plus bicuculline plus strychnine or with a low-Ca(2+)-high-Mg2+ medium failed to reduce their firing rate. The membrane trajectory consisted of one of two patterns interconvertible by injections of depolarizing or hyperpolarizing current: 1) depolarizing ramps leading to spikes or 2) slow oscillations (tetrodotoxin resistant but absent at hyperpolarized potentials) leading to spikes or repolarization. The cells had Ca(...Continue Reading

Citations

Aug 28, 2009·The Journal of Comparative Neurology·Roman M LazarenkoPatrice G Guyenet
Jan 16, 2010·Journal of Applied Physiology·Patrice G GuyenetRoy Kanbar
May 24, 2013·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Patrice G GuyenetStephen B G Abbott
Oct 26, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·A M Schreihofer, P G Guyenet
Jan 11, 2019·Frontiers in Neural Circuits·Tomas HökfeltSven Ove Ögren
Oct 30, 2008·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Naoki OshimaHiroshi Itoh
Aug 20, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Wei Sun, W Michael Panneton

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