C18-coated stir bar sorptive extraction combined with high performance liquid chromatography-electrospray tandem mass spectrometry for the analysis of sulfonamides in milk and milk powder

Talanta
Chunhe Yu, Bin Hu

Abstract

A simple, rapid, sensitive, inexpensive and less sample consuming method of C(18)-stir bar sorptive extraction (SBSE)-high performance liquid chromatography (HPLC)-tandem mass spectrometry (MS/MS) was proposed for the determination of six sulfonamides in milk and milk powder samples. C(18) silica particles coated stir bar was prepared by adhesion method, and two kinds of adhesive glue, polydimethylsiloxane (PDMS) sol and epoxy glue were tried. It was found that the C(18)-coated stir bar prepared by PDMS sol as adhesive glue is more robust than that prepared by epoxy glue when liquid desorption was employed, in terms of both lifetime and organic solvent tolerance. The preparation of C(18) stir bar was simple with good mechanic strength and the stir bar could be reused for more than 20 times. Granular coating has relatively high specific surface area and is propitious to sorptive extraction based process. Compared to conventional PDMS SBSE coating, C(18) coating shows good affinity to the target polar/weak polar sulfonamides. To achieve optimum SBSE extraction performance, several parameters including extraction and desorption time, ionic strength, sample pH and stirring speed were investigated. The detection limits of the propos...Continue Reading

References

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Citations

Oct 19, 2013·Analytical and Bioanalytical Chemistry·Man HeBin Hu
May 2, 2014·Food Additives & Contaminants. Part B, Surveillance·Nan ZhengZhongnuo Yu
Sep 9, 2015·Journal of Separation Science·Thanyaporn SukchuayOpas Bunkoed
Feb 16, 2015·Journal of Dairy Science·C GreletF Dehareng
Aug 2, 2017·Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering·Jackeline StoskiGilberto Abate
Nov 26, 2020·Analytical Methods : Advancing Methods and Applications·Natascha A TeixeiraGilberto Abate
Aug 22, 2021·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Sirintorn Jullakan, Opas Bunkoed

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