C1P Attenuates Lipopolysaccharide-Induced Acute Lung Injury by Preventing NF-κB Activation in Neutrophils

The Journal of Immunology : Official Journal of the American Association of Immunologists
Kristin BaudißMarco Idzko

Abstract

Recently, ceramide-1-phosphate (C1P) has been shown to modulate acute inflammatory events. Acute lung injury (Arnalich et al. 2000. Infect. Immun. 68: 1942-1945) is characterized by rapid alveolar injury, lung inflammation, induced cytokine production, neutrophil accumulation, and vascular leakage leading to lung edema. The aim of this study was to investigate the role of C1P during LPS-induced acute lung injury in mice. To evaluate the effect of C1P, we used a prophylactic and therapeutic LPS-induced ALI model in C57BL/6 male mice. Our studies revealed that intrapulmonary application of C1P before (prophylactic) or 24 h after (therapeutic) LPS instillation decreased neutrophil trafficking to the lung, proinflammatory cytokine levels in bronchoalveolar lavage, and alveolar capillary leakage. Mechanistically, C1P inhibited the LPS-triggered NF-κB levels in lung tissue in vivo. In addition, ex vivo experiments revealed that C1P also attenuates LPS-induced NF-κB phosphorylation and IL-8 production in human neutrophils. These results indicate C1P playing a role in dampening LPS-induced acute lung inflammation and suggest that C1P could be a valuable candidate for treatment of ALI.

References

Jul 1, 1996·American Journal of Respiratory and Critical Care Medicine·R P BaughmanE N Pattishall
Sep 1, 1997·The Journal of Clinical Investigation·H BöhrerP P Nawroth
Dec 5, 1998·The Journal of Biological Chemistry·V T Hinkovska-GalchevaJ A Shayman
May 4, 2000·The New England Journal of Medicine·L B Ware, M A Matthay
Jul 13, 2000·American Journal of Physiology. Lung Cellular and Molecular Physiology·S RosseauJ Lohmeyer
Mar 20, 2001·American Journal of Respiratory and Critical Care Medicine·Y KitamuraH Nakajima
Dec 6, 2001·American Journal of Respiratory and Critical Care Medicine·W Y ParkT R Martin
Mar 7, 2002·American Journal of Physiology. Lung Cellular and Molecular Physiology·Yongzheng WuLhousseine Touqui
Mar 11, 2003·American Journal of Respiratory and Critical Care Medicine·Kuang-Yao YangEdward Abraham
Jun 25, 2003·Biochemical and Biophysical Research Communications·Hyun-Ja JeongHyung-Min Kim
Oct 3, 2003·Journal of Lipid Research·Antonio Gómez-MuñozUrs P Steinbrecher
Dec 17, 2003·The Journal of Biological Chemistry·Benjamin J PettusCharles E Chalfant
Jan 27, 2004·The Journal of Pathology·Madhav Bhatia, Shabbir Moochhala
Feb 11, 2004·The Journal of Biological Chemistry·Susumu MitsutakeYasuyuki Igarashi
Mar 17, 2004·American Journal of Respiratory and Critical Care Medicine·Xinqi PengJoe G N Garcia
Sep 21, 2005·American Journal of Respiratory Cell and Molecular Biology·Michael A Matthay, Guy A Zimmerman
Oct 13, 2005·Journal of Cell Science·Charles E Chalfant, Sarah Spiegel
Jun 22, 2006·Current Drug Targets·Gye Young Park, John W Christman
Nov 3, 2006·The Journal of Clinical Investigation·Marco IdzkoBart N Lambrecht
Jun 15, 2007·Cellular and Molecular Life Sciences : CMLS·S Lahiri, A H Futerman
Feb 23, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Christine GrafFrédéric Bornancin
Jul 10, 2008·Molecular Pharmacology·Christine GrafFrédéric Bornancin
Jul 16, 2008·American Journal of Physiology. Lung Cellular and Molecular Physiology·Gustavo Matute-BelloThomas R Martin
Sep 2, 2008·American Journal of Physiology. Lung Cellular and Molecular Physiology·Rodolfo P VieiraCelso R F Carvalho
Nov 18, 2008·Translational Research : the Journal of Laboratory and Clinical Medicine·William S SzczepaniakBryan J McVerry
Dec 2, 2008·Cellular Signalling·María H GranadoAntonio Gómez-Muñoz
May 7, 2009·Biochimica Et Biophysica Acta·María H GranadoAntonio Gómez-Muñoz
Jul 28, 2009·The Journal of Biological Chemistry·Nadia F LamourCharles E Chalfant
Dec 17, 2009·Medicine and Science in Sports and Exercise·Daniel Souza RamosRodolfo de Paula Vieira
Feb 9, 2010·Lipids in Health and Disease·Lide AranaAntonio Gómez-Muñoz
May 29, 2010·American Journal of Respiratory Cell and Molecular Biology·Monica LucattelliMarco Idzko
Jun 19, 2010·Nature Chemical Biology·Henrik Fyrst, Julie D Saba
Nov 3, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Szczepan JózefowskiAndrzej Sobota
Nov 4, 2010·Molecular Medicine·Jochen Grommes, Oliver Soehnlein
Jan 8, 2011·Critical Care : the Official Journal of the Critical Care Forum·Maina M B MoralesMarisa Dolhnikoff
May 3, 2011·American Journal of Respiratory Cell and Molecular Biology·Gustavo Matute-BelloUNKNOWN Acute Lung Injury in Animals Study Group
Nov 9, 2011·The Journal of Biological Chemistry·Jody L HankinsMark Kester
Feb 3, 2012·Medicine and Science in Sports and Exercise·Rodolfo de Paula VieiraMarisa Dolhnikoff
Aug 2, 2012·The Journal of Clinical Investigation·Michael A MatthayGuy A Zimmerman
Oct 20, 2012·Critical Care : the Official Journal of the Critical Care Forum·Cintia Tokio Reis GonçalvesMarisa Dolhnikoff
Feb 16, 2013·Biochimica Et Biophysica Acta·Antonio Gomez-MuñozMiguel Trueba

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Citations

Dec 23, 2017·Mediators of Inflammation·Nitai C Hait, Aparna Maiti
Jan 19, 2018·Journal of Leukocyte Biology·Elena ChiricozziMassimo Aureli
Sep 21, 2018·American Journal of Physiology. Lung Cellular and Molecular Physiology·Jun YinWolfgang M Kuebler
Aug 23, 2019·Arteriosclerosis, Thrombosis, and Vascular Biology·Hebe Agustina MenaSoledad Negrotto
Jun 25, 2020·Essays in Biochemistry·Ana Gomez-LarrauriAntonio Gomez-Muñoz
May 5, 2017·JCI Insight·Maria Serena LonghiSimon C Robson
Dec 5, 2017·Experimental Lung Research·Enqin GuanJiang Hong
Mar 16, 2018·Mediators of Inflammation·Sabine GröschElisabetta Albi
Sep 7, 2018·BioMed Research International·Alaa N A FahmiHatem A Salem
Jun 21, 2019·Nature Communications·A MitrofanovaA Fornoni
Jan 21, 2021·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Mohamed AbdelmoneimSamia Hussein
Sep 20, 2020·Journal of Lipid Research·M Victoria SimonNawajes Mandal
Jan 21, 2020·Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids·Natalia PresaAntonio Gomez-Muñoz
Feb 9, 2021·Journal of Lipid Research·Simon M VictoriaMandal Nawajes
Aug 7, 2021·Medicina·Ana Gomez-LarrauriAlberto Ouro
Oct 23, 2020·Biomedical Journal·Shun-Chin YangTsong-Long Hwang

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