C1q nephropathy in a patient with Gitelman syndrome

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Consolación Rosado RubioJosé Luis Lerma Márquez


Bartter syndrome can manifest in three different forms and is rarely concomitant with glomerular nephropathies. However, this association is more frequently observed in children. We report the case of a 50-year-old woman with Gitelman syndrome for the past 30 years who also had a nephrotic syndrome of recent appearance. Her renal biopsy revealed hyperplasia of the juxtaglomerular apparatus and mesangial deposits of C1q, with no clinical or serological evidence of systemic erythematous lupus. We have not found any reports of instances of association of Gitelman syndrome and nephrotic syndrome arising from C1q nephropathy in adult patients. Our case suggests the possible existence of an association between hypokalaemic tubular nephropathies and glomerular nephropathies that may cause nephrotic syndrome.


May 4, 2000·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·M NishidaT Sawada
Sep 7, 2000·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·I H SuH Trachtman
Jul 2, 2003·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Yahya SardaniRobert L Rosenfield
Sep 13, 2003·Kidney International·Glen S MarkowitzVivette D D'Agati
Sep 7, 2006·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Coral HanevoldRory Dalton
Jul 25, 2008·Journal of the American Society of Nephrology : JASN·Alenka VizjakJ Charles Jennette

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