C1q nephropathy in the pediatric population: pathology and pathogenesis

Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
Scott E WenderferMichael C Braun

Abstract

C1q nephropathy was originally described nearly 25 years ago by Jennette and Hipp. Since that time there have been a limited number of publications on C1q nephropathy, most of them in the pediatric literature. Despite reported incidences as high as 16% in some pediatric biopsy series, a consensus definition on the diagnosis of C1q nephropathy is lacking and its existence as a distinct clinical disease entity remains controversial. The purpose of this review is to discuss the biology of C1q in the context of mechanisms of C1q deposition, and to provide a detailed analysis of the published pediatric case series with a focus on the pathological criteria used to establish the diagnosis of C1q nephropathy as well as long-term outcomes in children.

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Citations

Jul 16, 2013·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Mateja Vintar SpreitzerTanja Kersnik Levart
Dec 12, 2013·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Vindya N GunasekaraKjell Tullus
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May 18, 2016·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Thomas M ConnorCharles D Pusey
Mar 2, 2021·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Jarcy ZeeMatthew G Sampson

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