C1qTNF-related protein-6 mediates fatty acid oxidation via the activation of the AMP-activated protein kinase

FEBS Letters
Wan LeeSeung-Yoon Park

Abstract

C1qTNF-related proteins (CTRPs) are involved in diverse processes including metabolism, inflammation host defense, apoptosis, cell differentiation, autoimmunity, hibernation, and organogenesis. However, the physiological role of CTRP6 remains poorly understood. Here we demonstrate that the globular domain of CTRP6 mediates the phosphorylation and activation of the 5'-AMP-activated protein kinase (AMPK) in skeletal muscle cells. In parallel with the activation of AMPK, CTRP6 induces the phosphorylation of acetyl coenzyme A carboxylase (ACC) and fatty acid oxidation in myocytes. Thus, CTRP6 plays a role in fatty acid metabolism via the AMPK-ACC pathway.

References

May 16, 1997·The Journal of Biological Chemistry·D VavvasN B Ruderman
Nov 29, 2002·Proceedings of the National Academy of Sciences of the United States of America·Eva TomasNeil B Ruderman
Jun 13, 2003·Nature·Toshimasa YamauchiTakashi Kadowaki
Jan 20, 2004·Trends in Biochemical Sciences·David Carling
Jul 3, 2004·Proceedings of the National Academy of Sciences of the United States of America·Guang W WongHarvey F Lodish
Jul 23, 2004·The Journal of Biological Chemistry·Arzu Onay-BesikciGary D Lopaschuk
Sep 15, 2004·Trends in Immunology·Uday KishoreGerard J Arlaud
Mar 17, 2005·The Journal of Clinical Endocrinology and Metabolism·Michael B ChenGregory R Steinberg
Aug 27, 2005·Investigative Ophthalmology & Visual Science·Radha AyyagariPaul A Sieving
Apr 29, 2006·The Journal of Physiology·D Grahame HardieJohn W Scott
May 31, 2007·Molecular and Cellular Biochemistry·Hironori AkiyamaTakashi Maeda
Aug 8, 2007·Trends in Immunology·A SchäfflerB Salzberger
Jan 4, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jun Ho JeonYoung Yang
Sep 13, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·G William WongHarvey F Lodish

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Citations

Jul 24, 2010·Molecules and Cells·Mi-Jin KimSeung-Yoon Park
Apr 22, 2014·Trends in Endocrinology and Metabolism : TEM·Koji OhashiNoriyuki Ouchi
Jul 17, 2015·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·R StinkensE E Blaak
Feb 3, 2015·Cell Biology International·Wen-jing WuGong-she Yang
Apr 30, 2016·Acta Biochimica Et Biophysica Sinica·Wenjing WuGongshe Yang
May 8, 2016·Biochemical and Biophysical Research Communications·Rong-Hui FanWen-Jie Gao
Feb 6, 2017·Frontiers in Immunology·Martin Kolev, Claudia Kemper
May 9, 2012·Journal of Korean Medical Science·Mi-Jin KimSeung-Yoon Park
Feb 6, 2019·Journal of Cellular Biochemistry·Wei-Feng ZhengHao Wang
Feb 12, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nikolaj Kirketerp-MøllerPeter Garred
Jul 21, 2017·The Journal of Biological Chemistry·Xia LeiG William Wong
Jun 29, 2012·Molecular Biology Reports·Eun-Ju ParkSeung-Yoon Park
May 31, 2012·Molecular and Cellular Biochemistry·Mi-Jin KimSeung-Yoon Park

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