PMID: 6969058Oct 1, 1980Paper

C3, factor B, alpha-1-antitrypsin in neonatal septicaemia with sclerema

Archives of Disease in Childhood
B Pelet

Abstract

C3, factor B, and alpha-1-antitrypsin were determined in newborn infants with septicaemia and sclerema, associated with suspected infections, ABO or Rh incompatibility, and hyperbilirubinaemia of unknown origin, during and after treatment with exchange transfusion. Activation products from C3 and factor B, the clearance of the transfused C3, and its synthesis by the recipient were determined also. Infected newborn infants had low levels of C3 and factor B, but a normal amount of alpha-1-antitrypsin. Exchange transfusion lowered the level of alpha-1-antitrypsin and briefly corrected the low level of C3 and factor B. Activation products were formed only exceptionally. As synthesis of C3 is very active, a defective activation of complement pathway linked to an abnormal distribution in extravascular pool is postulated.

References

May 1, 1975·The New England Journal of Medicine·D T FearonW R McCabe
Sep 1, 1979·Archives of Disease in Childhood·B Pelet
Oct 1, 1978·The Journal of Pediatrics·D AdamkinR Spitzer
Jan 1, 1974·Annals of the New York Academy of Sciences·R A LiebeltA G Liebelt

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Citations

Aug 1, 1987·Pediatric Dermatology·D F Fretzin, A M Arias
Aug 1, 1990·Acta paediatrica Scandinavica·W Nürnberger, V Wahn
May 29, 2020·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Akanksha VermaAnita Singh
Mar 1, 1990·Annals of Tropical Paediatrics·R P SinghR Natarajan

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