C3 polymorphism in relation to age.

Human Heredity
H Sorensen, J Dissing

Abstract

The C3 phenotype distribution was investigated in different age-groups among 2,078 voluntary blood donors between the ages of 20 and 65 years, in a group of unrelated babies and in a group of old healthy persons. A continuous increase in the C3F gene frequency with age was found among the blood donors varying from 0.1780 in the youngest age group (babies: 0.1585) to 0.2516 at the age of 50-55 years followed by a continuous decrease to a level of 0.1700 among the eldest donors (01718 among the old persons). In the age group 45-49 years the C3 distribution differed significantly from that in the adjoining age-groups (C3F = 0.1619). It is believed that the variations are brought about by selection of the blood donor population and a balanced polymorphism for the C3 system, possibly due to differences in the biological efficiency of the C3 variants in the complement sequence.

Citations

Jan 1, 1984·Human Genetics·J R Regueiro, A Arnaiz-Villena
Apr 1, 1982·Revue française de transfusion et immuno-hématologie·C Davrinche, C Rivat
Jan 1, 1976·Transplantation Reviews·C JersildN K Day
Jan 1, 1983·Acta Medica Scandinavica. Supplementum·H Sørensen

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