C3a levels and occurrence of subdermal vascular thrombosis are age-related in deep second-degree burn wounds

Surgery
Hans-Günther MachensPeter Mailänder

Abstract

After second-degree burns, thrombosis of the subdermal vascular plexus may occur, necessitating epifascial necrectomy instead of tangential excision to ensure split skin graft healing. Until now, no parameter has been obtained to explain this phenomenon. Thirty-four patients with deep second-degree burn wounds were divided into 2 groups. In group 1, patients' age was < 60 years, in group 2, > 60 years. In each patient, 2 microdialysis catheters were introduced into subdermal tissue of deep second-degree thermal wounds immediately after admission. Another 2 catheters were introduced in control tissue. We measured biochemical parameters (lactate, glycerol and glucose) and complement 3a (C3a) until surgery was performed. The surgically removed tissue was examined histologically. In thermal wounds of both groups, glucose levels fell, but lactate and glycerol levels rose compared to healthy tissue. Within the first 24 hours after trauma, C3a levels were significant higher in both groups, compared with controls (P < .01). After 24 hours the levels in group 1 had fallen to nonsignificant values, while in group 2 these levels remained high until surgery was performed (P < .001). We found significantly more thrombotic blood vessels in d...Continue Reading

References

Oct 1, 1991·Journal of Internal Medicine·U Ungerstedt
Feb 1, 1997·Burns : Journal of the International Society for Burn Injuries·F L YehR H Fang
Sep 29, 2000·Critical Care Medicine·A RadkeM Kirschfink
May 23, 2002·Current Pharmaceutical Biotechnology·M StahlV Pay
Jun 7, 2003·The Journal of Burn Care & Rehabilitation·H J KangK M Lee
Oct 8, 2004·Critical Care : the Official Journal of the Critical Care Forum·Stephan KlausLudger Bahlmann
Mar 23, 2005·The Journal of Experimental Medicine·Ian Del CondeVahid Afshar-Kharghan

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Citations

Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Freeman SuberFrancis D Moore
Jan 24, 2009·Journal of Burn Care & Research : Official Publication of the American Burn Association·Franklin van de GootHans W M Niessen
Mar 7, 2009·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Lars J PetersenHenrik Kehlet
Aug 13, 2008·The Journal of Surgical Research·Anne BrueggemannHans-Guenther Machens
Jul 15, 2015·Journal of Neurotrauma·Zachary M WeilJohn D Corrigan
Jan 25, 2013·Clinical & Developmental Immunology·Gwendolyn CazanderPeter H Nibbering
May 20, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Franciska ErdőYukio Kato
May 31, 2019·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Markus DenzingerStefanie Krajewski
Mar 17, 2020·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Seung Taek LimYoung Jin Suh
Jan 21, 2021·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Seung Taek LimYoung Jin Suh

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