C3b/iC3b deposition on Streptococcus pneumoniae is not affected by HIV infection.

PloS One
Catherine HyamsStephen B Gordon

Abstract

Streptococcus pneumoniae is a common cause of infection in both HIV positive patients and those with complement deficiencies. We hypothesised that HIV positive individuals might exhibit reduced opsonisation of pneumococcus with complement due to reduced levels of S. pneumoniae specific IgG. We discovered no difference in C3 deposition on S. pneumoniae between HIV positive or negative individuals, and furthermore C3 deposition remained unchanged as HIV progressed towards AIDS. We found no correlation between C3 deposition on S. pneumoniae and CD4 cell count in HIV infected individuals. Hence we have demonstrated no failure of complement immunity in HIV positive patients.

References

Oct 1, 1979·The American Journal of Medicine·R Austrian
Jan 1, 1988·Medical Microbiology and Immunology·R Mayer-SiutaV A DeBari
Sep 1, 1985·The Journal of Pediatrics·L J BernsteinA Rubinstein
Aug 29, 1968·The New England Journal of Medicine·J A Winkelstein, R H Drachman
Jan 1, 1974·International Urology and Nephrology·Y Levo, A I Pick
Jan 8, 1999·Research in Virology·M B ValliL Bertolini
Mar 10, 1999·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·B G ChangV D D'Agati
Apr 5, 2001·The New England Journal of Medicine·M J Walport
Dec 13, 2002·Proceedings of the National Academy of Sciences of the United States of America·Jeremy S BrownMarina Botto
Nov 14, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Hidehiko TakahashiTsuyoshi Nagatake
Sep 12, 2007·PLoS Pathogens·Jose YusteJeremy S Brown
Jan 1, 1928·The Journal of Hygiene·F Griffith

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Methods Mentioned

BETA
flow cytometry

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