C4d complement split product in diagnosis of immunological activity of chronic allograft nephropathy

Transplantation Proceedings
Andrzej MrózMagdalena Durlik

Abstract

Activation of the humoral branch of the immunological response is currently believed to play an important role in pathogenesis of chronic allograft nephropathy. The impact of humoral alloreactivity, indicated by the presence of C4d deposits in peritubular capillaries of a renal allograft, on the development of chronic allograft nephropathy is a significant problem in transplantation. The aim of the study was to assess and correlate C4d expression in patients with chronic allograft nephropathy, with clinical and morphological variables, as well as to assess the impact of a change in immunosuppression regimen on posttransplant course and renal allograft morphology. Twenty-six patients with chronic allograft nephropathy underwent biopsies to correlate C4d expression with clinical parameters and morphological findings. In all patients azathioprine was replaced with mycophenolate mofetil with additional CsA dose reduction in 12 patients. After 1 year, 14 protocol biopsies were performed. The frequency of C4d peritubular capillary deposition among patients with chronic allograft nephropathy was 30%. C4d expression appeared later after transplantation, was correlated with chronic allograft glomerulopathy and proteinuria but not other ...Continue Reading

References

Dec 1, 1989·Kidney International·J ZwirnerH E Feucht
Sep 2, 1998·Transplantation Proceedings·B Kluth-PepperH E Feucht
Sep 1, 1999·Kidney International·L C Paul
Nov 27, 1999·Transplantation Proceedings·P HäyryH Savolainen
Jul 6, 2000·Immunopharmacology·A C Allison, E M Eugui
Feb 22, 2001·Journal of the American Society of Nephrology : JASN·Shamila MauiyyediRobert B Colvin
Aug 23, 2002·Journal of the American Society of Nephrology : JASN·Bruno Watschinger, Manuel Pascual
Oct 11, 2003·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Volker Nickeleit, Michael J Mihatsch

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Citations

Dec 20, 2007·Transplantation·Elias David-NetoDaísa Ribeiro David

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