C4d immunostaining is an independent predictor of cardiac allograft vasculopathy and death in heart transplant recipients

Transplant International : Official Journal of the European Society for Organ Transplantation
Adriana LukHeather J Ross

Abstract

Antibody-mediated rejection (AMR) occurs in 10-20% of patients after heart transplantation. C4d immunostaining is one parameter used in its diagnosis. This study aimed to determine whether C4d staining has prognostic significance for mortality, coronary allograft vasculopathy (CAV), cell-mediated rejection (CMR), and graft dysfunction in patients post-transplantation. Consecutive patients receiving an endomyocardial biopsy between 2007 and 2008 were selected. Left ventricular function, angiography, episodes of AMR/CMR, and death were noted. C4d was graded from 0 to 3 (immunostaining). Cox proportional models (recurrent events analysis) were used to evaluate C4d staining with mortality, graft dysfunction, CAV (≥grade 2), and episodes of ≥2R-CMR. We analyzed 2525 biopsy specimens (n = 217). During a follow-up of 4.5 ± 2 years, 35 died, 49 had graft dysfunction, seven had ≥grade 2 CAV, and 95 episodes of CMR occurred. A one-grade increase in C4d staining was associated with an increase in mortality (HR 1.57; 95% CI 1.0-2.5), a higher risk of CAV (HR 2.4, 95% CI 1.04-5.4), and a trend toward graft dysfunction (HR 1.42; 95% CI 1.0-2.09). C4d was not associated with CMR. C4d immunostaining was a significant predictor of CAV and death...Continue Reading

References

Jun 1, 1993·Kidney International·H E FeuchtE Albert
Oct 21, 1999·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·T M BehrC E Angermann
Aug 23, 2002·Journal of the American Society of Nephrology : JASN·Jeffrey L Platt
Jan 18, 2003·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Paul J MichaelsMichael C Fishbein
Apr 20, 2004·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Howard Eisen, Heather Ross
Jun 16, 2004·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Steven K TakemotoFrancis L Delmonico
Feb 26, 2005·Transplant International : Official Journal of the European Society for Organ Transplantation·Gerhard PoelzlSeverin Schwarzacher
Sep 7, 2005·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Rex Neal SmithA Bernard Collins
Nov 22, 2005·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Susan StewartMargaret E Billingham
May 7, 2009·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Grace W WuAbbas Ardehali
Jul 28, 2009·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Sachin GuptaMark H Drazner
Feb 6, 2010·Immunologic Research·Barbara A Wasowska
Mar 2, 2010·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Ellen L MoseleyMartin J Goddard
Jul 14, 2010·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Mandeep R MehraPatricia A Uber
Feb 9, 2011·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Jon KobashigawaUNKNOWN Consensus Conference Participants
Apr 9, 2011·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Nandini NairMandeep R Mehra
May 11, 2011·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Gerald J BerryMandeep R Mehra
Jun 15, 2011·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A LoupyJ P Duong Van Huyen
May 1, 2012·Journal of Transplantation·Sharon ChihVivek Rao
Feb 19, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·S ChihH J Ross

❮ Previous
Next ❯

Citations

Oct 17, 2020·Indian Journal of Thoracic and Cardiovascular Surgery : Official Organ, Association of Thoracic and Cardiovascular Surgeons of India·Sai Bhagra, Jayan Parameshwar

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation
Grace W WuAbbas Ardehali
The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation
Renee FrankPriti Lal
The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation
Ellen L MoseleyMartin J Goddard
The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation
Marny FedrigoAnnalisa Angelini
© 2021 Meta ULC. All rights reserved