C4d-negative antibody-mediated rejection with high anti-angiotensin II type I receptor antibodies in absence of donor-specific antibodies

Nephrology
Alexander FussPatrick T Coates

Abstract

Acute antibody-mediated rejection can occur in absence of circulating donor-specific antibodies. Agonistic antibodies targeting the anti-angiotensin II type 1 receptor (anti-AT1 R) are emerging as important non-human leucocyte antigen (HLA) antibodies. Elevated levels of anti-angiotensin II receptor antibodies were first observed in kidney transplant recipients with malignant hypertension and allograft rejection. They have now been studied in three separate kidney transplant populations and associate to frequency of rejection, severity of rejection and graft failure. We report 11 cases of biopsy-proven, Complement 4 fragment d (C4d)-negative, acute rejection occurring without circulating donor-specific anti-HLA antibodies. In eight cases, anti-angiotensin receptor antibodies were retrospectively examined. The remaining three subjects were identified from our centre's newly instituted routine anti-angiotensin receptor antibody screening. All subjects fulfilled Banff 2013 criteria for antibody-mediated rejection and all responded to anti-rejection therapy, which included plasma exchange and angiotensin receptor blocker therapy. These cases support the routine assessment of anti-AT1 R antibodies in kidney transplant recipients to ...Continue Reading

References

Apr 9, 1999·The Journal of Clinical Investigation·G WallukatF C Luft
Jun 24, 2004·British Journal of Pharmacology·Shu-Meng ChengJenn-Haung Lai
Feb 11, 2005·The New England Journal of Medicine·Duska DragunGerd Wallukat
May 11, 2005·Kidney International·Jon A WeidanzBryan N Becker
Mar 16, 2007·Journal of the American Society of Nephrology : JASN·Robert B Colvin
May 23, 2007·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Duska Dragun
Mar 20, 2010·The Journal of Biological Chemistry·Hamiyet UnalSadashiva S Karnik
Jul 11, 2013·Current Opinion in Organ Transplantation·Duska DragunAurélie Philippe
Aug 8, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M GiralD Dragun
Aug 15, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M TaniguchiP I Terasaki
Jan 30, 2014·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M HaasUNKNOWN Banff meeting report writing committee
Jun 10, 2014·Transplant International : Official Journal of the European Society for Organ Transplantation·Mirosław BanasikMarian Klinger
Sep 3, 2014·American Journal of Respiratory and Critical Care Medicine·Mike O BeckerGabriela Riemekasten

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Citations

Sep 13, 2015·Current Cardiology Reports·Beje Thomas, Matthew R Weir
May 18, 2016·Kidney International·Duska DragunAurélie Philippe
Jun 28, 2016·Nature Reviews. Nephrology·Qiuheng Zhang, Elaine F Reed
Oct 19, 2016·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Isabella GuzzoLuca Dello Strologo
Nov 1, 2016·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·E CozziF Rea
May 10, 2017·International Journal of Environmental Research and Public Health·Jian ZhangLe Ma
Feb 15, 2018·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Alexander FichtnerBurkhard Tönshoff
Jun 4, 2016·Current Opinion in Organ Transplantation·Mary Carmelle Philogene, Annette M Jackson
May 20, 2020·International Journal of Immunogenetics·Xiaohai Zhang, Nancy L Reinsmoen
Apr 30, 2017·Frontiers in Immunology·Xiaohai Zhang, Nancy L Reinsmoen
Jul 8, 2017·Transplant International : Official Journal of the European Society for Organ Transplantation·Clement DeltombeMagali Giral
Nov 8, 2015·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Juhan LeeUNKNOWN KNOW-KT Study Group
Apr 5, 2017·Journal of Immunology Research·Carrie L ButlerElaine F Reed
Nov 17, 2020·Transplantation·Edward John Filippone, John L Farber
Aug 31, 2021·Frontiers in Immunology·Alexander McQuistonCarl Atkinson

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