C6 mediates chronic progression of tubulointerstitial damage in rats with remnant kidneys.

Journal of the American Society of Nephrology : JASN
Masaomi NangakuWilliam G Couser

Abstract

Although it was once considered only a marker of glomerular damage, accumulating evidence indicates that proteinuria per se is nephrotoxic and contributes to the progression of renal injury. Several studies have demonstrated that activation of complement in proteinuric urine results in tubular and interstitial damage. It was previously demonstrated that acute complement-mediated interstitial disease is induced by C5b-9. Here the role of C5b-9 in the progression of chronic proteinuric renal disease was investigated in a nonimmunologic remnant kidney model. Five-sixths nephrectomies were performed for normocomplementemic control and C6-deficient PVG rats. Tubulointerstitial injury was assessed by measurement of two independent markers of tubular injury (i.e., vimentin and osteopontin), interstitial accumulation of the extracellular matrix components collagen type I, collagen type IV, and laminin, interstitial macrophage infiltration, and renal function. The two groups developed similar levels of proteinuria and BP. Whereas C3 deposition on the brush border was equivalent for rats in the two groups, C5b-9 deposition was observed only for normocomplementemic rats. At day 35, the degrees of both tubulointerstitial injury and renal f...Continue Reading

References

Jul 1, 1992·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·K A Nath
Dec 1, 1970·Human Pathology·L I SchainuckE P Benditt
Apr 1, 1995·Histopathology·T N Khan, R Sinniah
Jun 1, 1994·Kidney International·D Kees-FoltsG F Schreiner
Jul 1, 1993·Kidney International·G FujisawaT Saito
Jun 1, 1996·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·C Burton, K P Harris
Jan 1, 1997·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·S DavidG Camussi
Jun 15, 1997·The Journal of Clinical Investigation·T S JohnsonA Meguid El Nahas
Sep 19, 1997·Journal of the American Society of Nephrology : JASN·Y MoritaS Matsuo
Nov 14, 1997·Journal of the American Society of Nephrology : JASN·A JunaidT H Hostetter
Jan 24, 1998·Journal of the American Society of Nephrology : JASN·H N Ibrahim, T H Hostetter
Oct 10, 1998·Kidney International·M GandhiT W Meyer
Nov 13, 1998·The New England Journal of Medicine·G Remuzzi, T Bertani
Nov 26, 1998·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·S MatsuoY Yuzawa
Jun 3, 1999·Kidney & Blood Pressure Research·N S Sheerin, S H Sacks
Nov 30, 1999·Journal of the American Society of Nephrology : JASN·M NangakuW G Couser
Apr 7, 2000·Journal of the American Society of Nephrology : JASN·Yoshiki MoritaSeiichi Matsuo
Apr 15, 2000·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·W F Keane

❮ Previous
Next ❯

Citations

Apr 28, 2020·Expert Opinion on Therapeutic Targets·Sandra Rayego-Mateos, Jose M Valdivielso
Feb 22, 2003·Journal of the American Society of Nephrology : JASN·William G Couser
Apr 23, 2003·Journal of the American Society of Nephrology : JASN·Mauro Abbate, Giuseppe Remuzzi
May 23, 2003·Journal of the American Society of Nephrology : JASN·Carla ZojaGiuseppe Remuzzi
Aug 26, 2003·Journal of the American Society of Nephrology : JASN·Masaomi Nangaku
Sep 30, 2003·Journal of the American Society of Nephrology : JASN·Lihua BaoRichard J Quigg
Nov 26, 2003·Journal of the American Society of Nephrology : JASN·William A WilmerLee A Hebert
Sep 26, 2002·Clinical and Experimental Immunology·N S Sheerin, S H Sacks
Oct 24, 2002·Current Opinion in Nephrology and Hypertension·Steven H Sacks, Paramit Chowdhury
Mar 13, 2003·Kidney International·Timothy W Meyer
Apr 17, 2003·Current Opinion in Nephrology and Hypertension·Frank Eitner, Jürgen Floege
Apr 17, 2003·Current Opinion in Nephrology and Hypertension·Takahiko NakagawaRichard J Johnson
Apr 20, 2004·Current Opinion in Nephrology and Hypertension·Carla ZojaGiuseppe Remuzzi
Sep 8, 2004·International Immunopharmacology·Igor L BykovKai O Lindros
Oct 16, 2004·Kidney International. Supplement·Kambiz Zandi-NejadBarry M Brenner
Jan 28, 2005·Kidney International·Wilhelm Kriz, Michel LeHir
Jan 28, 2005·Kidney International·Gopala K RanganWilliam G Couser
Apr 1, 2005·Journal of the American Society of Nephrology : JASN·Patrick N Cunningham, Richard J Quigg
Apr 1, 2005·Journal of the American Society of Nephrology : JASN·Masaomi NangakuWilliam G Couser
Aug 20, 2005·Circulation Research·Erdenechimeg ShagdarsurenDominik N Muller
Apr 12, 2005·Current Opinion in Nephrology and Hypertension·Daniel Turnberg, H Terence Cook
Jul 15, 2005·Kidney International·Kevin Sean Eardley, Paul Cockwell
Feb 3, 2006·Journal of the American Society of Nephrology : JASN·Neil S SheerinSteven H Sacks
Nov 18, 2005·Journal of the American Society of Nephrology : JASN·Masaomi Nangaku
Sep 30, 2010·Kidney International·William G Couser, Masaomi Nangaku
Jan 18, 2006·Annual Review of Medicine·Raymond C Harris, Eric G Neilson
Mar 3, 2006·Journal of the American Society of Nephrology : JASN·Tammo OstendorfJürgen Floege
Apr 1, 2006·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Masaomi Nangaku
Apr 13, 2006·Current Opinion in Nephrology and Hypertension·Carla ZojaGiuseppe Remuzzi
Oct 13, 2006·Journal of the American Society of Nephrology : JASN·Allison A Eddy, Agnes B Fogo
Oct 13, 2006·Journal of the American Society of Nephrology : JASN·Mauro AbbateGiuseppe Remuzzi
Dec 28, 2006·Journal of the American Academy of Dermatology·Katherine E Vasil, Cynthia M Magro
Mar 29, 2007·Journal of the American Society of Nephrology : JASN·Peter BoorTammo Ostendorf
Apr 26, 2007·Nature Clinical Practice. Nephrology·Katherine M BrownNeil S Sheerin
Jul 4, 2007·Laboratory Investigation; a Journal of Technical Methods and Pathology·Tomoki KosugiKenji Kadomatsu
Sep 29, 2007·Seminars in Immunopathology·Stefan P Berger, Mohamed R Daha
Nov 28, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Neil S SheerinSteven H Sacks
Mar 21, 2008·Journal of the American Society of Nephrology : JASN·Mauro AbbateGiuseppe Remuzzi
Aug 30, 2008·American Journal of Physiology. Renal Physiology·Hilde GaarkeukenStefan P Berger

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alternative Complement Pathway

The Alternative Complement Pathway is part of the innate immune system, and activation generates membrane attack complexes that kill pathogenic cells. Discover the latest research on the Alternative Complement Pathway.