C6orf106 enhances NSCLC cell invasion by upregulating vimentin, and downregulating E-cadherin and P120ctn

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Xiu-Peng ZhangEnhua Wang

Abstract

Chromosome 6 open reading frame 106 (C6orf106) is a newly discovered protein; its expression and clinical pathological significance in human tumors remains unclear. Immunohistochemistry, Western blot, and immunofluorescence were performed to assess C6orf106 expression in non-small cell lung cancer (NSCLC). In addition, the relationships between subcellular localization and clinical pathological factors were analyzed. Through C6orf106 overexpression and repression, respectively, in lung cancer cell lines, we explored the effect of this molecule on NSCLC invasion abilities. C6orf106 was highly expressed in the cytoplasm of lung cancer tissue cells (60.4 %, 75/124), compared with adjacent normal lung tissues (15.2 %, 7/46, p < 0.001). In addition, its expression was positively correlated with differentiation (p = 0.001), TNM stage (p = 0.011), lymph node metastasis (p = 0.018), and poor prognosis (p = 0.006). Furthermore, C6orf106 overexpression enhanced NSCLC cell invasion. Moreover, C6orf106 was shown to increase vimentin expression, while decreasing E-cadherin and P120ctn. C6orf106 is highly expressed in NSCLC and correlates with clinical and pathological factors, as well as poor prognosis. C6orf106 promotes invasion in NSCLC c...Continue Reading

References

Mar 5, 1999·Breast Cancer Research and Treatment·S MénardM I Colnaghi
Oct 24, 2003·Nature·A J MungallS Beck
May 20, 2004·Cancer Research·Vered Givant-HorwitzReuven Reich
Jun 11, 2005·Endocrine-related Cancer·V BernoE Tagliabue
Sep 3, 2009·Molecular Therapy : the Journal of the American Society of Gene Therapy·Jonathan ScheimanDaniel Meruelo
Sep 14, 2010·The International Journal of Biochemistry & Cell Biology·Paul W SouJ Guy Lyons
Oct 12, 2011·Surgical Oncology Clinics of North America·Peter Goldstraw
Oct 13, 2011·Molecular Systems Biology·Jian WangXiaoming Yang
Jul 4, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Dae Gyu KimSunghoon Kim
Jan 28, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Shan-Chun ZhangKun Chen
Jun 2, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Mousumi TaniaJunjiang Fu

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Citations

May 29, 2018·The Journal of Biological Chemistry·Rebecca L AmbroseCameron R Stewart

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