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C9orf72-derived arginine-containing dipeptide repeats associate with axonal transport machinery and impede microtubule-based motility

bioRxiv

Nov 8, 2019

Laura FumagalliPhilip Van Damme

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Abstract

Hexanucleotide repeat expansions in the C9orf72 gene are the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). How this mutation leads to these neurodegenerative diseases remains unclear. Here, we use human induced pluripotent stem cell-...read more

Mentioned in this Paper

Amyotrophic Lateral Sclerosis
Axonal Transport
Brain
Cell Growth
Cell Motility
Microtubules
Mitochondria
Nerve Degeneration
Neurons
Kinesin
53
5
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C9orf72-derived arginine-containing dipeptide repeats associate with axonal transport machinery and impede microtubule-based motility

bioRxiv

Nov 8, 2019

Laura FumagalliPhilip Van Damme

DOI: 10.1101/835082

Abstract

Hexanucleotide repeat expansions in the C9orf72 gene are the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). How this mutation leads to these neurodegenerative diseases remains unclear. Here, we use human induced pluripotent stem cell-...read more

Mentioned in this Paper

Amyotrophic Lateral Sclerosis
Axonal Transport
Brain
Cell Growth
Cell Motility
53
5

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