CA-125 in fine-needle aspirates of solid tumors: comparison with cytologic diagnosis and carcinoembryonic antigen (CEA) assay

Diagnostic Cytopathology
M M Pinto, S Kotta

Abstract

One hundred and twenty-two fine needle aspirates (FNA) from female patients were studied to determine whether CA-125 assay contributed to cytologic diagnosis and CEA assay. Cytologic examination was done on Papanicolaou-stained smears and cell blocks, CEA by EIA (Abbott Laboratory, > 5 ng/ml cutoff) and CA-125 by RIA (Abbott Laboratory, North Chicago, IL, > 66 mu/ml cutoff). Final diagnosis were correlated with histologic diagnosis when available, clinical, radiologic studies, and follow-up. 29 benign, 93 malignant. Sensitivities and specificities: cytology, 91%, 100%; CEA: 59%, 86%; CA-125, 50%, 55%. CEA plus cytology sensitivity, 97%. CA-125 content was highest in endometrial/ovarian carcinoma (39,899 mu/ml) and < 5,000 mu/ml in other tumors and benign FNA in contrast to CEA which showed highest levels in carcinomas of colon, pancreas, and lung (> 280 ng/ml). While elevated CEA enhances the sensitivity of cytologic diagnosis of carcinomas of the colon, pancreas, and lung, low CEA and high CA-125 content supports an ovarian/endometrial primary.

References

Mar 1, 1987·Histopathology·I A KoelmaG J Fleuren
Jan 1, 1985·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·C Cordon-CardoK O Lloyd
Jan 1, 1983·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·S E KabawatR B Colvin
Mar 1, 1994·Fertility and Sterility·A BarbatiG Montanino

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