Ca(2+)-activated K(+) channels as therapeutic targets for myocardial and vascular protection.

Circulation Journal : Official Journal of the Japanese Circulation Society
Richard T ClementsFrank W Sellke

Abstract

Small- and large-conductance Ca(2+)-activated K(+)channels (SKCa and BKCa, respectively) may be important targets for therapeutic interventions in a variety of cardiac conditions. In cardiomyocytes, BKCa channels are localized to mitochondria where they beneficially modulate reactive oxygen species, mitochondrial Ca(2+), and respiration. In vascular smooth muscle cells, BKCa channels regulate vascular tone and promote vasodilation. Activation of BKCa channels has demonstrated significant cardioprotection following ischemic injury, including improved function and reduced infarct size. SKCa channels are expressed in both the membrane and mitochondria of cardiomyocytes. Modulation of cardiomyocyte SKCa channels may be beneficial for arrhythmia, heart failure, and ischemia. Mitochondrial SKCa channels may provide similar benefit to BKCa channels. In addition, activation of SKCa channels on the endothelium promotes vasodilation. This mini-review focuses on the modulation of cardiomyocyte BKCa and SKCa channels for cardioprotection and briefly address associated potential therapeutic benefits in the coronary circulation.

References

Sep 26, 2003·Biochimica Et Biophysica Acta·Keith D Garlid, Petr Paucek
Jun 9, 2004·The Journal of Biological Chemistry·Andrea L MeredithRichard W Aldrich
Sep 21, 2004·Nature Reviews. Neuroscience·Martin Stocker
Jul 7, 2005·The Journal of Biological Chemistry·Sergey I ZakharovSteven O Marx
Aug 2, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Dipika TutejaNipavan Chiamvimonvat
Aug 30, 2005·American Journal of Physiology. Heart and Circulatory Physiology·David F StoweMing-Tao Jiang
Sep 22, 2005·Physiology·Brian O'RourkeMiguel A Aon
Oct 22, 2005·The Journal of Physiology·Rong LuLigia Toro
Jan 31, 2006·Physiology·Jonathan LedouxMark T Nelson
Jul 28, 2006·American Journal of Physiology. Cell Physiology·André HeinenDavid F Stowe
Nov 18, 2006·Circulation Research·Ling LuNipavan Chiamvimonvat
May 22, 2007·American Journal of Physiology. Heart and Circulatory Physiology·André HeinenAmadou K S Camara
Jul 7, 2007·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Jarrod D KnudsonJohnathan D Tune
Aug 19, 2007·Trends in Pharmacological Sciences·Stephen P Soltoff
Apr 9, 2008·Physiological Reviews·Elizabeth Murphy, Charles Steenbergen
Jun 24, 2008·Experimental Neurology·Bogusz KulawiakWolfram S Kunz
Sep 3, 2008·Pflügers Archiv : European journal of physiology·Bo Hjorth BentzenMorten Grunnet
Jun 23, 2009·Nature Reviews. Neuroscience·Rafael LujánJohn P Adelman
Feb 25, 2010·FEBS Letters·Adam SzewczykKrzysztof Dołowy
Apr 13, 2010·Pflügers Archiv : European journal of physiology·Gillian EdwardsArthur H Weston
Jul 28, 2010·Biochemical Society Transactions·Andrew P Halestrap
Oct 21, 2010·Proceedings of the National Academy of Sciences of the United States of America·Min LiLigia Toro
Dec 7, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Hui XuGregory D Fink
Feb 8, 2011·Journal of Cardiovascular Pharmacology·Qin YangGuo-Wei He
Oct 11, 2011·Molecular Pharmacology·Janos Almassy, Ted Begenisich
Dec 7, 2011·PloS One·Andrew P WojtovichKeith Nehrke
Feb 15, 2012·Proceedings of the National Academy of Sciences of the United States of America·Guido GessnerStefan H Heinemann
Aug 30, 2012·The Journal of Physiology·Harpreet SinghLigia Toro
Oct 16, 2012·Circulation Research·Andrew M WaltersPaul S Brookes
Oct 23, 2012·American Journal of Physiology. Heart and Circulatory Physiology·Le GuiQing-Hui Chen
Mar 26, 2013·Journal of the American Heart Association·Po-Cheng ChangTomohiko Ai
Apr 2, 2013·American Journal of Physiology. Heart and Circulatory Physiology·Piotr BednarczykAdam Szewczyk
Jun 12, 2013·Proceedings of the National Academy of Sciences of the United States of America·Harpreet SinghLigia Toro

❮ Previous
Next ❯

Citations

Apr 5, 2017·Journal of Cardiovascular Pharmacology·Friederike BehmenburgMarc M Berger
Jun 14, 2015·American Journal of Physiology. Heart and Circulatory Physiology·Brenda CordeiroRichard T Clements
Aug 29, 2020·Cells·Margarida LorigoElisa Cairrao
Feb 23, 2021·Pulmonary Circulation·Guogu LiuAiguo Dai
Jul 16, 2020·Biophysical Journal·Peter BronkBum-Rak Choi
Apr 16, 2021·Journal of Molecular and Cellular Cardiology·Shanna HamiltonDmitry Terentyev
Apr 14, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Monika KubackaSzczepan Mogilski

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.