Ca2+ and cAMP regulations of microtubule sliding in hyperactivated motility of bull spermatozoa

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences
Sumio Ishijima

Abstract

To reach and fertilize the egg, mammalian spermatozoa change their flagellar movement in the female reproductive tract, named hyperactivation. The biochemical analyses of the hyperactivated movement using demembranated spermatozoa defined the factors inducing this peculiar movement; namely, large asymmetrical flagellar movement observed in the early stage of the hyperactivation was induced with a high Ca(2+) concentration while large symmetrical flagellar movement in the late stage of the hyperactivation was generated with low Ca(2+) and high cAMP concentrations. Under these conditions, the microtubule sliding of bull sperm flagella was investigated by disintegrating the sperm flagella with MgATP(2-) after extracting their plasma membrane and mitochondria. The large asymmetrical flagellar movement was caused by a long sliding displacement of a fiber of the doublet microtubules. On the other hand, the large symmetrical flagellar movement was generated by a large amount of microtubule sliding by many doublet microtubules.

References

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Mar 18, 2003·Journal of Cell Science·Izumi NakanoChikako Shingyoji
Mar 25, 1959·The Journal of Biophysical and Biochemical Cytology·B AFZELIUS
Dec 8, 2004·Reproduction : the Official Journal of the Society for the Study of Fertility·Masashi KinukawaFugaku Aoki
Aug 10, 2007·Cell Motility and the Cytoskeleton·Sumio Ishijima
Jul 26, 2008·Human Reproduction Update·Susan S Suarez
Jun 15, 2011·Reproduction : the Official Journal of the Society for the Study of Fertility·Sumio Ishijima
Jan 21, 2012·Biology of Reproduction·Kathleen A LesichCharles B Lindemann

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Citations

Jun 13, 2018·Biology of Reproduction·C Sánchez-CárdenasA Darszon
Oct 22, 2016·Cytoskeleton·Charles B Lindemann, Kathleen A Lesich
Aug 8, 2021·International Journal of Molecular Sciences·Agnieszka MostekAndrzej Ciereszko

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Software Mentioned

Bohboh
SPSS
Dipp
Motion

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