Ca2+ as a mediator of ischemic preconditioning

Circulation Research
H Miyawaki, M Ashraf

Abstract

We tested the hypothesis that elevation of [Ca2+]i during ischemic preconditioning (IPC) stimulates protein kinase C (PKC), which confers the protection against the ischemic injury. Langendorff-perfused rat hearts were subjected to 40-minute global ischemia followed by 30-minute reperfusion (I/R). In preconditioned groups, hearts were subjected to either IPC, consisting of 5-minute global ischemia and 10-minute reperfusion, or high-Ca2+ preconditioning (HCPC), ie, the 5-minute perfusion of higher Ca2+ perfusate (2.3 mmol/L Ca2+) followed by 10-minute perfusion of normal perfusate (1.8 mmol/L Ca2+), and then were subjected to I/R. A significant functional recovery and decreased lactate dehydrogenase release were observed in HCPC and IPC hearts compared with ischemic control hearts. ATP contents of preconditioned hearts were significantly higher than those of the ischemic control hearts. The cell structure in preconditioned hearts was preserved better than that in the ischemic control hearts. Furthermore, the activation and translocation of PKC from cytoplasm to sarcolemma were observed in the preconditioned hearts. Verapamil administered during IPC significantly attenuated the salutary effects of IPC. Administration of cheleryth...Continue Reading

References

Sep 1, 1992·Canadian Journal of Physiology and Pharmacology·Y QuA K Sen
Oct 1, 1992·The American Journal of Physiology·Y Liu, J M Downey
Jan 1, 1992·Cardiovascular Research·G Heusch
Apr 1, 1992·The Journal of Cell Biology·W C WetselY A Hannun
Jan 1, 1990·Annual Review of Physiology·M Tani
Nov 15, 1990·Biochemical and Biophysical Research Communications·J M HerbertJ P Maffrand
Sep 15, 1988·Nature·A E LacerdaA M Brown
Jul 18, 1986·Science·Y Nishizuka
Aug 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·E MarbanV P Chacko
Aug 1, 1987·The American Journal of Physiology·P R MorrisonF W Booth
Aug 1, 1994·Journal of Molecular and Cellular Cardiology·H A van HeugtenJ M Lamers
May 1, 1993·The American Journal of Physiology·T A Kohout, T B Rogers
Jan 1, 1995·Journal of Molecular and Cellular Cardiology·H W De JongeJ M Lamers
Sep 1, 1993·The Biochemical Journal·R C VenemaJ F Kuo
Apr 15, 1993·The Biochemical Journal·H Hug, T F Sarre
Jul 1, 1996·Physiological Reviews·D A Jans, S Hübner
Jun 1, 1996·Journal of Molecular and Cellular Cardiology·J P Headrick
Nov 1, 1992·Trends in Cardiovascular Medicine·J H Brown, E A Martinson

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Citations

Jun 30, 2010·Pflügers Archiv : European journal of physiology·Nicolas DuquesnesBertrand Crozatier
Jun 7, 2005·The Journal of Surgical Research·Jeffrey M PitcherDaniel R Meldrum
Dec 5, 2003·Journal of Molecular and Cellular Cardiology·Raúl J DomenechPilar Macho
Jun 5, 2003·Experimental Neurology·Masatoshi YunokiKevin S Lee
Jul 7, 2000·Pharmacology & Therapeutics·A NakanoJ M Downey
May 18, 1999·International Journal of Cardiology·R Carroll, D M Yellon
May 16, 1998·Trends in Microbiology·A Casadevall
Feb 27, 2003·Clinical and Experimental Pharmacology & Physiology·Amanda FloodJohn P Headrick
Feb 7, 2012·Antioxidants & Redox Signaling·Yi-Hong LiuJin-Song Bian
Jul 23, 1999·Annals of the New York Academy of Sciences·K PrzyklenkR A Kloner
Jun 9, 2000·Annual Review of Physiology·M V CohenJ M Downey
Apr 2, 2009·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Shaminder KaurAmteshwar S Jaggi
Nov 11, 1999·Proceedings of the National Academy of Sciences of the United States of America·R TianJ S Ingwall
Apr 25, 2000·Journal of Molecular and Cellular Cardiology·B S CainA H Harken
Apr 11, 2000·Journal of Molecular and Cellular Cardiology·G J Grover, K D Garlid
Aug 17, 1999·Current Opinion in Cardiology·E R SchwarzR A Kloner
Feb 12, 2002·Scandinavian Cardiovascular Journal : SCJ·K Ylitalo, K Peuhkurinen
Mar 24, 2009·Life Sciences·Thorsten MaierKlaus-Dieter Schlüter
Feb 13, 2007·Transplant International : Official Journal of the European Society for Organ Transplantation·Joan Torras AmbrosJosep M Grinyo Boira
Jun 1, 2005·Vascular Pharmacology·Yigang WangMuhammad Ashraf
Jan 21, 2000·Journal of Molecular and Cellular Cardiology·B S CainA H Harken
Oct 20, 1999·Journal of Molecular and Cellular Cardiology·G S LiuJ M Downey
Oct 27, 1999·The Journal of Surgical Research·B S CainA H Harken
Mar 17, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Anindita DasRakesh C Kukreja
Dec 29, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R CariniE Albano
Jan 26, 2016·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Hee Jung KimShin Hee Yoon
May 23, 2002·The Journal of Pharmacology and Experimental Therapeutics·Hong Yan ZhangZhenhai Yao

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