Ca2+, autophagy and protein degradation: thrown off balance in neurodegenerative disease.

Cell Calcium
J M VicencioG Szabadkai

Abstract

Substantial progress has been made throughout the last decades in the elucidation of the key players and mechanisms responsible for Ca2+ signal generation in both excitable and non-excitable cells. Importantly, these studies led also to the recognition that a close correlation exists between the deregulation of cellular Ca2+ homeostasis and the development of several human pathologies, including neurodegenerative disease. Notwithstanding this advances, much less is certain about the targets and mechanisms by which compromised Ca2+ signaling exerts its effects on cell function and survival. Recently it has been proposed that deregulation of cellular energy metabolism and protein turnover (synthesis, folding and degradation) are also fundamental pathomechanisms of neurodegenerative disease, pointing to the pivotal role of autophagy, a major cellular pathway controlling metabolic homeostasis. Indeed, activation of autophagy has been shown to represent a highly successful strategy to restore normal neuronal function in a variety of models of neurodegenerative disease. Here we review recent advances in elucidating Ca2+ regulation of autophagy and will highlight its relationship to neurodegeneration.

Citations

Jan 11, 2012·Journal of Inherited Metabolic Disease·J E DavisonC J Hendriksz
May 12, 2012·International Journal of Cell Biology·Yi-Bing Ouyang, Rona G Giffard
Aug 29, 2012·Future Medicinal Chemistry·Christopher W JohnsonAi Yamamoto
May 28, 2013·Current Translational Geriatrics and Experimental Gerontology Reports·Xiao-Xin YanA Jeromin
Feb 23, 2011·Archives of Biochemistry and Biophysics·Tsuyoshi TakitaHiroko Inoue
Jan 31, 2014·American Journal of Medical Genetics. Part a·Felippe BorlotChong Ae Kim
Dec 15, 2010·Biochimica Et Biophysica Acta·Jean-Paul DecuypereJan B Parys
Mar 23, 2011·Journal of Aging Research·Jean-Paul DecuypereGeert Bultynck
Nov 16, 2011·Autophagy·Jean-Paul DecuypereGeert Bultynck
Jun 17, 2016·Expert Review of Cardiovascular Therapy·Jaime A RiquelmeSergio Lavandero
Sep 10, 2016·Evidence-based Complementary and Alternative Medicine : ECAM·Zhen-Tao MoQi-Hai Gong
Jul 1, 2017·Metallomics : Integrated Biometal Science·Dongmei SongPiye Niu
Oct 21, 2011·Physiological Reviews·Olga CortiAlexis Brice
Nov 20, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Fang SunBei Zhang
Aug 4, 2021·Biotechnology and Applied Biochemistry·Marzieh AsadiAmir Savardashtaki

❮ Previous
Next ❯

Related Concepts

Related Feeds

Parkinson's Disease & Autophagy

Autophagy leads to degradation of damaged proteins and organelles by the lysosome. Impaired autophagy has been implicated in several diseases. Here is the role of autophagy in Parkinson’s disease.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Autophagosome

An autophagosome is the formation of double-membrane vesicles that involve numerous proteins and cytoplasmic components. These double-membrane vesicles are then terminated at the lysosome where they are degraded. Discover the latest research on autophagosomes here.

Alzheimer's Disease: Endosomes

Dysfunctional endosomal trafficking may be associated with Alzheimer’s disease (AD) pathology. Targeting the endosome may advance treatment options for AD. Here is the latest research on endosomes and AD.

AKT Pathway

This feed focuses on the AKT serine/threonine kinase, which is an important signaling pathway involved in processes such as glucose metabolism and cell survival.

Autophagy & Disease

Autophagy is an important cellular process for normal physiology and both elevated and decreased levels of autophagy are associated with disease. Here is the latest research.

Autophagosome

An autophagosome is the formation of double-membrane vesicles that involve numerous proteins and cytoplasmic components. These double-membrane vesicles are then terminated at the lysosome where they are degraded. Discover the latest research on autophagosomes here.

Autophagy & Metabolism

Autophagy preserves the health of cells and tissues by replacing outdated and damaged cellular components with fresh ones. In starvation, it provides an internal source of nutrients for energy generation and, thus, survival. A powerful promoter of metabolic homeostasis at both the cellular and whole-animal level, autophagy prevents degenerative diseases. It does have a downside, however--cancer cells exploit it to survive in nutrient-poor tumors.

Calcium & Bioenergetics

Bioenergetic processes, including cellular respiration and photosynthesis, concern the transformation of energy by cells. Here is the latest research on the role of calcium in bioenergetics.

Parkinson's Disease & Autophagy (MDS)

Autophagy leads to degradation of damaged proteins and organelles by the lysosome. Impaired autophagy has been implicated in several diseases. Here is the role of autophagy in Parkinson’s disease.

Autophagy Networks

Autophagy is a lysosomal pathway that involves degradation of proteins and functions in normal growth and pathological conditions, through a series of complex networks. The catabolic process involves delivery of proteins and organelles to the lysosome. Here is the latest research on autophagy networks.

BCL-2 Family Proteins

BLC-2 family proteins are a group that share the same homologous BH domain. They play many different roles including pro-survival signals, mitochondria-mediated apoptosis and removal or damaged cells. They are often regulated by phosphorylation, affecting their catalytic activity. Here is the latest research on BCL-2 family proteins.

Autophagy & Model Organisms

Autophagy is a cellular process that allows degradation by the lysosome of cytoplasmic components such as proteins or organelles. Here is the latest research on autophagy & model organisms

Related Papers

The Journal of Biological Chemistry
M Tariq Khan, Suresh K Joseph
Cold Spring Harbor Perspectives in Biology
Michael W Harr, Clark W Distelhorst
Current Molecular Medicine
C GiorgiR Rizzuto
Biochimica Et Biophysica Acta
Virginia ToddeIda J van der Klei
© 2021 Meta ULC. All rights reserved