PMID: 9162739Feb 1, 1997Paper

Ca(2+)-binding proteins S100A6 and S100B in primary cutaneous melanoma

Journal of Cutaneous Pathology
R BöniG Burg

Abstract

Commercially available polyclonal antibodies against a mixture of bovine brain S100 proteins have become an established marker for immunohistochemical characterization of malignant melanoma. However, the commercially available antibodies used are undefined and to date, 13 different human S100 proteins are known. The purpose of this study was to examine the expression of 4 newly available polyclonal antibodies against the human recombinant Ca(2+)-binding S100 proteins, S100A1, S100A2, S100A4 and S100A6, in cutaneous melanoma and to correlate these findings with the standard S100 staining as well as with the metastatic potential of the primary. 39 formalin-fixed paraffin-embedded primary cutaneous melanomas were incubated with polyclonal antibodies against recombinant human S100 proteins using the APAAP method. The extent of staining was qualitatively assessed and a staining index was calculated. Findings were correlated to the metastatic potential and the overall survival in all patients. Staining with antibodies against human S100A6 as well as with antibodies against conventional bovine S100 proteins was positive in all specimens. No correlation was found between the extent of protein expression and patients' outcome for standa...Continue Reading

References

Mar 1, 1991·Trends in Biochemical Sciences·C W Heizmann, W Hunziker
Oct 1, 1988·American Journal of Clinical Pathology·N G OrdóñezR C Hickey
Dec 1, 1987·Histopathology·N M Kernohan, R Rankin
Jun 9, 1965·Biochemical and Biophysical Research Communications·B W Moore
Feb 1, 1984·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·J L CordellD Y Mason
May 1, 1981·European Journal of Biochemistry·T Isobe, T Okuyama
Jun 1, 1994·International Journal of Cancer. Journal International Du Cancer·M PedrocchiC W Heizmann
Oct 1, 1993·Melanoma Research·A J CochranD R Wen
Apr 1, 1996·Trends in Biochemical Sciences·B W Schäfer, C W Heizmann

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Citations

Dec 7, 2002·Journal of Photochemistry and Photobiology. B, Biology·Giuseppe MonfrecolaPietro Santoianni
Mar 26, 2003·The American Journal of Dermatopathology·Adriana Ribé, N Scott McNutt
Dec 31, 1998·Journal of Cutaneous Pathology·N S McNutt
Jan 21, 2006·The British Journal of Ophthalmology·S KeijserR J W de Keizer
Dec 19, 2013·Obstetrics and Gynecology International·J O Awoleke
Jun 18, 2010·The Journal of Investigative Dermatology·Bonnie E Gould Rothberg, David L Rimm
Jan 19, 2008·Journal of Cutaneous Pathology·Douglas R FullenDafydd Thomas
Jun 5, 2004·The Journal of Biological Chemistry·Jing LinDavid J Weber
Apr 22, 2005·Histopathology·Y ItoA Miyauchi
Jan 15, 2008·Journal of Cutaneous Pathology·Puja Kumari PuriDirk Elston
Nov 3, 2010·Journal of Cutaneous Pathology·Puja K PuriDirk M Elston
Jul 27, 2000·The Journal of Biological Chemistry·J C DeloulmeJ Baudier
Jul 2, 2003·Journal of Cutaneous Pathology·Hye-Rim Park, Soo Kee Min
Jan 20, 2016·International Journal of Oncology·Taiki MasudaKenichi Sugihara
Jun 13, 2001·Journal of Cutaneous Pathology·D R FullenN S McNutt
Jul 8, 2008·Journal of Molecular Biology·Thomas H CharpentierDavid J Weber

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