Ca2(+)-calmodulin-dependent protein kinase II phosphorylates various types of non-epithelial intermediate filament proteins

Biochemical and Biophysical Research Communications
T TokuiM Inagaki

Abstract

We have investigated the actions of Ca2(+)-calmodulin (CaM)-dependent protein kinase II on various types of non-epithelial intermediate filament proteins, vimentin, desmin, glial fibrillary acidic protein (GFAP) and neurofilament triplet proteins. Most of these filament proteins could serve as substrates. The effects of phosphorylation on the filamentous structure of vimentin were investigated in sedimentation experiments and by using electron microscopy. The amount of unassembled vimentin increased linearly with increased phosphorylation. However, the extent of the effect of phosphorylation on the potential to polymerize was also affected by the MgCl2 concentration, under conditions for reassembly. The actions of Ca2(+)-CaM-dependent protein kinase II on non-epithelial intermediate filaments under physiological conditions are given attention.

References

Nov 25, 1979·Journal of Molecular Biology·D C RuegerA Bignami
Mar 30, 1990·Biochemical and Biophysical Research Communications·Y GondaM Inagaki
Jan 1, 1985·Annual Review of Biochemistry·A C NairnP Greengard
Mar 15, 1989·Biochemical Pharmacology·R E White, H C Hartzell
May 1, 1980·Journal of Biochemistry·M YazawaK Yagi
Jan 14, 1983·Biochemical and Biophysical Research Communications·T Yamauchi, H Fujisawa
Jan 1, 1984·Annual Review of Biophysics and Bioengineering·R K GuptaR D Moore
Jan 1, 1984·The Journal of Membrane Biology·P W Flatman
Jun 25, 1981·Journal of Molecular Biology·W RennerE Mandelkow

❮ Previous
Next ❯

Citations

Apr 1, 1995·Cellular and Molecular Neurobiology·R ChertoffD M Michaelson
Feb 1, 1992·Current Opinion in Cell Biology·J E ErikssonR D Goldman
Nov 1, 1995·The Journal of Cell Biology·M OgawaraH Sugiura
Nov 21, 1992·Annals of the New York Academy of Sciences·G Bellomo, F Mirabelli
Oct 23, 2003·Annual Review of Cell and Developmental Biology·Brian T HelfandRobert D Goldman
Oct 5, 2013·Histochemistry and Cell Biology·Daniel L WinterZhenlin Li
Mar 29, 1991·Biochemical and Biophysical Research Communications·S AndoM Inagaki
Mar 29, 2002·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Masaaki TakemuraShigeyoshi Itohara
Feb 17, 2005·The Journal of Biological Chemistry·Svetlana ErmakovaZigang Dong
Feb 3, 2006·Human Molecular Genetics·Takahiro SasakiShin-Ichi Hisanaga
Jan 30, 2003·European Journal of Cell Biology·Wing ChanLouis Lim
Jan 12, 2010·Cellular Signalling·Kathryn A SkeldingJohn A P Rostas

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.