Ca(2+) current facilitation determines short-term facilitation at inhibitory synapses between cerebellar Purkinje cells

The Journal of Physiology
Françoise Díaz-RojasShin-ya Kawaguchi

Abstract

Short-term facilitation takes place at GABAergic synapses between cerebellar Purkinje cells (PCs). By directly patch clamp recording from a PC axon terminal, we studied the mechanism of short-term facilitation. We show that the Ca(2+) currents elicited by high-frequency action potentials were augmented in a [Ca(2+) ]i -dependent manner. The facilitation of synaptic transmission showed 4-5th power dependence on the Ca(2+) current facilitation, and was abolished when the Ca(2+) current amplitude was adjusted to be identical. Short-term facilitation of Ca(2+) currents predominantly mediates short-term facilitation at synapses between PCs. Short-term synaptic facilitation is critical for information processing of neuronal circuits. Several Ca(2+) -dependent positive regulations of transmitter release have been suggested as candidate mechanisms underlying facilitation. However, the small sizes of presynaptic terminals have hindered the biophysical study of short-term facilitation. In the present study, by directly recording from the axon terminal of a rat cerebellar Purkinje cell (PC) in culture, we demonstrate a crucial role of [Ca(2+) ]i -dependent facilitation of Ca(2+) currents in short-term facilitation at inhibitory PC-PC syna...Continue Reading

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Citations

Mar 15, 2016·Frontiers in Synaptic Neuroscience·Christoph Körber, Thomas Kuner
Feb 12, 2019·Scientific Reports·Amanda M BrownRoy V Sillitoe
Oct 27, 2017·The Journal of Physiology·Javier Zorrilla de San MartinShin-Ya Kawaguchi
May 3, 2020·Proceedings of the National Academy of Sciences of the United States of America·Laura C GomezIsabel Llano

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