Ca2+ currents in cardiac myocytes: Old story, new insights

Progress in Biophysics and Molecular Biology
Fabien BretteLaurent Sallé

Abstract

Calcium is a ubiquitous second messenger which plays key roles in numerous physiological functions. In cardiac myocytes, Ca2+ crosses the plasma membrane via specialized voltage-gated Ca2+ channels which have two main functions: (i) carrying depolarizing current by allowing positively charged Ca2+ ions to move into the cell; (ii) triggering Ca2+ release from the sarcoplasmic reticulum. Recently, it has been suggested than Ca2+ channels also participate in excitation-transcription coupling. The purpose of this review is to discuss the physiological roles of Ca2+ currents in cardiac myocytes. Next, we describe local regulation of Ca2+ channels by cyclic nucleotides. We also provide an overview of recent studies investigating the structure-function relationship of Ca2+ channels in cardiac myocytes using heterologous system expression and transgenic mice, with descriptions of the recently discovered Ca2+ channels alpha(1D) and alpha(1E). We finally discuss the potential involvement of Ca2+ currents in cardiac pathologies, such as diseases with autoimmune components, and cardiac remodeling.

References

Nov 1, 1978·The American Journal of Physiology·E Page
Feb 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·R J DieboldA Schwartz
Jul 20, 1992·FEBS Letters·D Singer-LahatN Dascal
Jun 1, 1992·Pflügers Archiv : European journal of physiology·E BourinetJ Nargeot
Aug 1, 1992·Biophysical Journal·M D Stern
Aug 1, 1992·The Journal of Physiology·X Xu, P M Best
Mar 1, 1992·Pflügers Archiv : European journal of physiology·C RomaninH Schindler
Aug 1, 1991·Circulation Research·N Tohse, N Sperelakis
Aug 1, 1991·European Heart Journal·U KühlB E Strauer
Aug 1, 1991·The Journal of General Physiology·R W Hadley, W J Lederer
Aug 1, 1991·Journal of Molecular and Cellular Cardiology·D J BeuckelmannE Erdmann
Jan 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·D T YueE Marban
Feb 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·P F MéryR Fischmeister
Jan 1, 1991·Journal of Molecular and Cellular Cardiology·H OuadidJ Nargeot
Jun 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·K L ChoiG Yellen
Oct 26, 1990·Science·E Niggli, W J Lederer
Jan 1, 1990·The American Journal of Physiology·M Näbauer, M Morad
Apr 20, 1990·Science·W J LedererR W Hadley
Jul 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·R Mitra, M Morad
Jul 1, 1986·Journal of Molecular and Cellular Cardiology·R W TsienM C Nowycky

❮ Previous
Next ❯

Citations

Nov 14, 2007·Basic Research in Cardiology·Pietro Enea LazzeriniFranco Laghi-Pasini
Jul 3, 2008·European Journal of Applied Physiology·Sen WangKe Jiang Cao
Dec 17, 2008·The Journal of Biological Chemistry·Omar RamadanMohamed Boutjdir
Aug 11, 2007·Journal of Bioinformatics and Computational Biology·Virginia González-Vélez, Horacio González-Vélez
Aug 16, 2008·The Journal of Clinical Investigation·V Arvydas SkeberdisRodolphe Fischmeister
Apr 19, 2008·BMC Molecular Biology·Alicia M EbertDeborah M Garrity
Feb 18, 2014·Science·Fabien BretteBarbara A Block
Sep 9, 2008·Annals of Biomedical Engineering·Nico H L KuijpersPeter A J Hilbers
Jul 20, 2010·Progress in Retinal and Eye Research·Jonathan J Henry, Panagiotis A Tsonis
Sep 18, 2007·Progress in Biophysics and Molecular Biology·Laurent SalléFabien Brette
Sep 21, 2007·Progress in Biophysics and Molecular Biology·M PásekC H Orchard
Jan 16, 2007·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Dan XuHui Wang
Feb 18, 2014·The Journal of Membrane Biology·Rimantas TreinysV Arvydas Skeberdis
Feb 5, 2013·Journal of Molecular and Cellular Cardiology·Fabien BretteLaurent Sallé
Oct 31, 2009·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Ahmad S AminArthur A M Wilde
Oct 20, 2011·Progress in Neurobiology·Henry C Tuckwell
May 3, 2014·Progress in Neurobiology·Henry C Tuckwell, Nicholas J Penington
Jul 8, 2008·Biochemical and Biophysical Research Communications·Fabien BretteHolly A Shiels
Jun 15, 2007·Physiology·Fabien Brette, Clive Orchard
Nov 8, 2014·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Caroline CrosFabien Brette
Jun 1, 2018·Journal of Diabetes Research·L Al KuryF C Howarth
Apr 16, 2019·Frontiers in Physiology·Vyacheslav S KorkoshBoris S Zhorov
Sep 25, 2007·Progress in Biophysics and Molecular Biology·Michal PásekGeorges Christé
Dec 5, 2020·Journal of Diabetes Research·Lina T Al Kury

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Cardiac Conduction System

The cardiac conduction system is a specialized tract of myocardial cells responsible for maintaining normal cardiac rhythm. Discover the latest research on the cardiac conduction system here.

Atrial Filbrillation

Atrial fibrillation refers to the abnormal heart rhythm characterized by rapid and irregular beating of the atria. Here is the latest research.

Advanced Imaging of Cellular Signaling

Cell signaling is a vital mechanism for communication within cells and outside with the environment. Several different signaling pathways have been found and advanced imaging techniques are being developed to visualize the molecules involved in these signaling pathways. Find the latest research in advanced imaging of cellular signaling here.

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.

Alternative splicing

Alternative splicing a regulated gene expression process that allows a single genetic sequence to code for multiple proteins. Here is that latest research.

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Calcium & Bioenergetics

Bioenergetic processes, including cellular respiration and photosynthesis, concern the transformation of energy by cells. Here is the latest research on the role of calcium in bioenergetics.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Caveolins & Signal Transduction

Caveolins are small proteins with a hairpin loop conformation that are located in the plasma membrane of various cell types where they bind cholesterol and interact with receptors essential for several signal transduction pathways. Here is the latest research.

Bradyarrhythmias

Bradyarrhythmias are slow heart rates. Symptoms may include syncope, dizziness, fatigure, shortness of breath, and chest pains. Find the latest research on bradyarrhythmias here.

Cardiovascular Homeostasis

Cardiovascular regulation and homeostasis is important in maintaining health and dysfunction may lead to cardiovascular diseases. Nitric oxide and vascular endothelium are one of many molecules involved in the homeostatic mechanism. Here is the latest research on cardiovascular homeostasis.