Ca2(+)-dependent and independent mechanisms of sustained contraction in vascular smooth muscle of rat aorta

Japanese Journal of Pharmacology
H OzakiH Karaki

Abstract

Norepinephrine (NE), prostaglandin F2 alpha (PG), 12-deoxyphorbol 13-isobutyrate (DPB) and high K+ induced sustained increase in cytosolic Ca2+ [( Ca2+]i) and muscle tension in rat aorta. Verapamil, at the concentration which abolished the high K(+)-induced changes, also abolished the increase in [Ca2+]i due to NE, PG and DPB although contractions were only partially inhibited. Excess EGTA further decreased [Ca2+]i although a part of the contraction was not inhibited. These results indicate that the sustained contractions induced by NE, PG and DPB are due to increase in [Ca2+]i, increase in Ca2+ sensitivity of contractile elements, and a Ca2(+)-independent mechanism.

Citations

Apr 16, 1998·European Journal of Pharmacology·M TosunR M Rapoport
Nov 6, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Kyungjin LeeHo-Young Choi
Dec 29, 2010·International Journal of Vascular Medicine·Darío EcheverriAngélica Prieto
Mar 1, 1993·Circulation Research·H Katsuyama, K G Morgan
Jan 1, 1997·International Journal of Urology : Official Journal of the Japanese Urological Association·Y Yoshimura, O Yamaguchi
Aug 2, 2007·Journal of Pharmacological Sciences·Takeharu KanedaKazumasa Shimizu
Aug 1, 1991·The American Journal of Physiology·E SuematsuK G Morgan
Feb 18, 1992·European Journal of Pharmacology·A Abe, H Karaki
Nov 13, 1990·European Journal of Pharmacology·J AnabukiH Karaki

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