Ca2+ dynamics in a population of smooth muscle cells: modeling the recruitment and synchronization

Biophysical Journal
Michèle KoenigsbergerJean-Jacques Meister

Abstract

Many experimental studies have shown that arterial smooth muscle cells respond with cytosolic calcium rises to vasoconstrictor stimulation. A low vasoconstrictor concentration gives rise to asynchronous spikes in the calcium concentration in a few cells (asynchronous flashing). With a greater vasoconstrictor concentration, the number of smooth muscle cells responding in this way increases (recruitment) and calcium oscillations may appear. These oscillations may eventually synchronize and generate arterial contraction and vasomotion. We show that these phenomena of recruitment and synchronization naturally emerge from a model of a population of smooth muscle cells coupled through their gap junctions. The effects of electrical, calcium, and inositol 1,4,5-trisphosphate coupling are studied. A weak calcium coupling is crucial to obtain a synchronization of calcium oscillations and the minimal required calcium permeability is deduced. Moreover, we note that an electrical coupling can generate oscillations, but also has a desynchronizing effect. Inositol 1,4,5-trisphosphate diffusion does not play an important role to achieve synchronization. Our model is validated by published in vitro experiments obtained on rat mesenteric arteria...Continue Reading

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Citations

Sep 11, 2012·Journal of Chemical Biology·Md Jahoor AlamB Indrajit Sharma
Jul 7, 2005·Bulletin of Mathematical Biology·Michèle KoenigsbergerJean-Jacques Meister
Aug 18, 2010·Proceedings of the National Academy of Sciences of the United States of America·Jens A LundbaekOlaf S Andersen
Jul 20, 2011·Proceedings of the National Academy of Sciences of the United States of America·Per GreisenJens A Lundbæk
Apr 16, 2008·The Journal of General Physiology·Jens A Lundbaek
Nov 27, 2009·Journal of the Royal Society, Interface·Jens A LundbaekOlaf S Andersen
Jul 18, 2008·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Jens Christian Brings JacobsenNiels-Henrik Holstein-Rathlou
Oct 5, 2010·Acta Physiologica·R K Pradhan, V S Chakravarthy
Apr 27, 2011·Acta Physiologica·C AalkjærV Matchkov
Dec 27, 2011·Critical Reviews in Biomedical Engineering·Adam KapelaNikolaos M Tsoukias
Jun 25, 2005·The Journal of Chemical Physics·Gennady V Miloshevsky, Peter C Jordan
Apr 17, 2009·The Journal of Chemical Physics·Christopher P CalderonIoan Kosztin
May 21, 2005·The Journal of Physiology·Rebecca E Haddock, Caryl E Hill
Apr 22, 2008·Journal of Theoretical Biology·Adam KapelaNikolaos M Tsoukias
Jul 1, 2008·Biophysical Journal·Michèle KoenigsbergerJean-Jacques Meister
Jan 29, 2005·British Journal of Pharmacology·Christian Aalkjaer, Holger Nilsson
Feb 22, 2012·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Sridevi NagarajaNikolaos M Tsoukias
Nov 10, 2010·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Nikolaos Michael Tsoukias
Nov 10, 2009·The FEBS Journal·Mohammad S ImtiazDirk F van Helden
Oct 5, 2011·IEEE Transactions on Bio-medical Engineering·Jeremy LaforetCatherine Marque
Mar 14, 2007·Biophysical Journal·Mohammad S ImtiazDirk F van Helden
Apr 4, 2016·Journal of Theoretical Biology·Bjørn Olav Hald
Jul 21, 2010·Biophysical Journal·Michèle KoenigsbergerJean-Jacques Meister
Dec 30, 2011·Computers in Biology and Medicine·Teodor BuchnerPaweł Kuklik
Jun 21, 2012·Biophysical Journal·Michael NivalaZhilin Qu
Feb 22, 2012·Biophysical Journal·Adam KapelaNikolaos M Tsoukias
Mar 29, 2005·Biophysical Journal·Michèle KoenigsbergerJean-Jacques Meister
Jun 6, 2006·Biophysical Journal·Michèle KoenigsbergerJean-Jacques Meister
Jul 26, 2005·Biophysical Journal·Mohammad S ImtiazDirk F van Helden
Jun 23, 2016·Experimental Biology and Medicine·Josef RosenbergMilan Stengl
Oct 5, 2017·Proceedings of the National Academy of Sciences of the United States of America·Paul Stevenson, Andrei Tokmakoff
Mar 10, 2007·Circulation Research·Vladimir V MatchkovHolger Nilsson
Aug 1, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Jean-Louis BényRoger Sauser
Mar 21, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Jens Christian Brings JacobsenNiels-Henrik Holstein-Rathlou

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