Ca(2+) entry blocking and contractility promoting actions of norbormide in single rat caudal artery myocytes

British Journal of Pharmacology
Fabio FusiSergio Bova


1 Aim of the present study was to investigate the effects of norbormide, a selective vasoconstrictor agent of the rat peripheral vessels, on the whole-cell voltage-dependent L-type Ca(2+) current (I(Ca(L))) of freshly isolated smooth muscle cells from the rat caudal artery, using either the conventional or the amphotericin B-perforated whole-cell patch-clamp method. 2 Norbormide decreased L-type Ca(2+) current in a concentration- and voltage-dependent manner, without modifying the threshold and the maximum of the current-voltage relationship. Norbormide-induced I(Ca(L)) inhibition was reversible upon wash-out. 3 Norbormide both shifted the voltage dependence of the steady-state inactivation curve to more negative potentials by about 16 mV, without affecting the activation curve, and decreased the slope of inactivation. Norbormide, however, did not modify both the activation and the inactivation kinetics of the I(Ca(L)). 4 Norbormide decreased I(Ca(L)) progressively during repetitive step depolarizations, with inhibition depending on the stimulation frequency (use-dependent block) as well as on the holding potential. 5 Addition of 50 micro M norbormide caused the contraction of all freshly isolated cells and also of those impale...Continue Reading


Nov 1, 1978·The Journal of Experimental Medicine·H E IvesJ D Jamieson
Mar 1, 1991·Journal of Neuroscience Methods·J RaeM Watsky
Jan 1, 1988·Annals of the New York Academy of Sciences·T B BoltonI MacKenzie
Oct 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·B P Bean
Aug 1, 1981·Pflügers Archiv : European journal of physiology·O P HamillF J Sigworth
Aug 22, 2000·British Journal of Pharmacology·J W WegenerH Nawrath
Apr 6, 2002·British Journal of Pharmacology·Simona SaponaraFabio Fusi

❮ Previous
Next ❯


Jun 12, 2003·European Journal of Pharmacology·Sergio BovaFabio Fusi
May 7, 2003·The Journal of Steroid Biochemistry and Molecular Biology·Giuliano NeriGastone G Nussdorfer
Oct 11, 2016·Frontiers in Pharmacology·Claudio D'AmoreSergio Bova
Jun 15, 2005·Biochimica Et Biophysica Acta·Fernanda RicchelliSergio Bova
Jan 25, 2005·The Journal of Pharmacology and Experimental Therapeutics·Fabio FusiSimona Saponara
Nov 20, 2009·The Journal of Pharmacology and Experimental Therapeutics·Fabio FusiSimona Saponara
May 5, 2016·Chemistry & Biodiversity·Hans ChoiDavid Rennison
Feb 27, 2007·Bioorganic & Medicinal Chemistry·David RennisonMargaret A Brimble
May 19, 2007·Biochimica Et Biophysica Acta·Alessandra ZulianFernanda Ricchelli

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Acta Crystallographica. Section C, Crystal Structure Communications
Peter J SteelDavid Rennison
A P RoszkowskiR J Mohrbacher
© 2021 Meta ULC. All rights reserved