PMID: 9425119Feb 28, 1998Paper

Ca2+ entry into PC12 cells initiated by ryanodine receptors or inositol 1,4,5-trisphosphate receptors

The Biochemical Journal
D L BennettT R Cheek

Abstract

Capacitative Ca2+ entry (CCE) is a universal mechanism for refilling intracellular Ca2+ stores in electrically non-excitable cells. The situation in excitable cells is less clear, however, since they may rely on other entry mechanisms for Ca2+-store refilling. In the present study we investigated CCE in intact PC12 cells, using acetylcholine to bring about activation of InsP3 receptors (InsP3Rs), caffeine to activate ryanodine receptors (RyRs) and thapsigargin to inhibit sarco/endoplasmic reticulum Ca2+-ATPase pumps. We found that depletion of the InsP3-, caffeine- or thapsigargin-sensitive stores promoted Ca2+ entry, suggesting that stimulation of either InsP3Rs or RyRs can activate CCE. The CCE pathways activated by InsP3Rs, RyRs and thapsigargin appeared to be independent at least in part, since their effects were found to be additive. However, CCE triggered by caffeine, acetylcholine or thapsigargin progressively diminished with time. The decay of CCE caused by one agent also inhibited subsequent responses to the others, suggesting that some component of the CCE pathway is common to all intracellular Ca2+ stores. The magnitude of CCE stimulated by InsP3Rs or RyRs was related to the size of the stores; the InsP3-sensitive st...Continue Reading

Citations

May 25, 2002·The European Journal of Neuroscience·Sacha McKenzie, Philip D Marley
Dec 2, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Amanda Jabin GustafssonMd Shahidul Islam
May 13, 2008·Environmental Health Perspectives·Milou M L DingemansRemco H S Westerink
Nov 20, 2010·Cellular and Molecular Neurobiology·Kelly L AdamsAndrew G Ewing
Jun 25, 2013·American Journal of Physiology. Heart and Circulatory Physiology·Helen E CollinsJohn C Chatham
Oct 17, 2013·Journal of Muscle Research and Cell Motility·Pura BolañosCarlo Caputo
Feb 1, 2010·Biophysics Reviews·Oliver FriedrichFrederic von Wegner
Jul 31, 2001·The Journal of Biological Chemistry·E R FlynnJ G McCarron
Apr 1, 2008·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Ji-Hwa HanShin Hee Yoon
Jun 16, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·D J TurnerM W Mulholland
Jan 10, 2004·Journal of Neurochemistry·Takashi YonedaYoshihiko Funae
Jan 19, 2005·Journal of Pharmacological Sciences·Kana KuniedaToshihiko Murayama
May 30, 2002·The Journal of Biological Chemistry·Schuichi KoizumiAndreas Jeromin
Apr 7, 2004·British Journal of Pharmacology·Shanthala PadarRoshanak Rahimian
Nov 7, 2002·The Journal of Biological Chemistry·Dong Wook ShinJianjie Ma
Jan 14, 1999·The American Journal of Physiology·P E SquiresA M Buchan
Feb 5, 2014·Toxicon : Official Journal of the International Society on Toxinology·Tomohiko KayanoTadanori Aimi
Jun 22, 1999·Cellular Signalling·A H Guse
May 25, 2002·Kidney International·Susan K Fellner, William J Arendshorst
Sep 29, 2004·Cell Calcium·Karl E O AkermanJyrki P Kukkonen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.