PMID: 8611160Feb 1, 1996Paper

Ca2+ entry modulates oscillation frequency by triggering Ca2+ release

The Biochemical Journal
T J Shuttleworth, J L Thompson

Abstract

As in many cells, the frequency of agonist-induced cytosolic Ca2+ concentration ([Ca2+]1) oscillations in exocrine avian nasal gland cells is dependent on the rate of Ca2+ entry. Experiments reveal that the initiation of each oscillatory spike is independent of the relative fullness of the stores and, furthermore, the oscillating pool is normally fully refilled by the end of each [Ca2+]1 spike. Therefore, contrary to current models, the interspike interval (which essentially sets the frequency) does not reflect the time taken to recharge the oscillating stores. Instead, the data show that it is the previously demonstrated role that Ca2+ entry plays in triggering the repetitive release of Ca2+ from the oscillating stores, rather than the recharging of those stores, that provides the basis for the observed effects of Ca2+ entry rate on oscillation frequency.

Citations

Jan 11, 2003·The Journal of Biological Chemistry·Olivier MignenTrevor J Shuttleworth
Feb 15, 2003·The Journal of Biological Chemistry·György SzabadkaiRosario Rizzuto
Oct 30, 2004·The Journal of Physiology·Gary St J Bird, James W Putney
Nov 18, 2004·Physiology·Trevor J ShuttleworthOlivier Mignen
Sep 6, 1996·The Journal of Biological Chemistry·T J Shuttleworth
Jan 22, 2004·Proceedings of the National Academy of Sciences of the United States of America·J SneydT J Shuttleworth
Oct 22, 2005·The Journal of Physiology·Noel McHaleKeith Thornbury
Mar 12, 2005·The Journal of Physiology·L JohnstonN G McHale
Aug 1, 2015·PloS One·Alejandro Guzmán-SilvaRoberto Berra-Romani
May 1, 1999·The Journal of Experimental Zoology·T J Shuttleworth, J P Hildebrandt
Oct 22, 2014·Journal of Bioenergetics and Biomembranes·Figen Amber CicekMehmet Ugur
Oct 26, 1999·The Journal of Biological Chemistry·T J Shuttleworth, J L Thompson
Jul 23, 2003·The Journal of Biological Chemistry·Olivier MignenTrevor J Shuttleworth
Jul 27, 2001·The Journal of Biological Chemistry·O MignenT J Shuttleworth
Jul 29, 2004·Science's STKE : Signal Transduction Knowledge Environment·Trevor J Shuttleworth
Dec 15, 2005·Zoology : Analysis of Complex Systems, ZACS·J P Hildebrandt

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