PMID: 8593247Nov 1, 1995Paper

Ca2+ entry through the store-mediated pathway directly activates only the K+ current but the subsequent Ca2+ release from the store activates both K+ and Cl- currents in submandibular gland acinar cells of the rat

Cellular Signalling
M WakuiA Nishiyama

Abstract

The store-mediated Ca2+ entry was detected in single and cluster of rat submandibular acinar cells by measuring the Ca2+ activated ionic membrane currents. In the cells where intracellular Ca2+ was partly depleted by stimulation with submaximal concentration of acetylcholine (ACh) under a Ca2(+)-free extracellular condition, an employment of external Ca2+ in the absence of ACh caused a sustained increase of the K+ current without affecting the Cl- current. A renewed ACh challenge without external Ca2+ caused repetitive spikes of both K+ and Cl- currents due to the Ca2+ release. SK & F 96365 inhibited the generation of the sustained K+ current and refilling of the Ca2+ store following the Ca2+ readmission. It is suggested that the Ca2+ enters the cell through the store-mediated pathway new the K+ channels and is taken up by the store. Thus, only Ca2+ released from the store can activate both the K+ and Cl- currents.

References

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Citations

Sep 5, 2002·Respiratory Physiology & Neurobiology·Nobuhisa IwaseYoshio Maruyama
Apr 27, 2000·American Journal of Respiratory Cell and Molecular Biology·T TamadaK Shirato
Apr 1, 1996·The Tohoku Journal of Experimental Medicine·Y FukushiM Wakui
Feb 14, 1998·Journal of Cellular Physiology·T TakeoM Wakui

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