PMID: 7540321Apr 1, 1995Paper

Ca(2+)-independent nitric oxide synthase activity in human lung after cardiopulmonary bypass

Thorax
R DelgadoM Palacios

Abstract

Because surgery involving cardiopulmonary bypass induces a systemic inflammatory response, the effect of cardiopulmonary bypass on nitric oxide (NO) generation was investigated in human lung tissue. Nitric oxide synthase (NOS) activity was measured by the conversion of 14C-L-arginine to 14C-L-citrulline in tissue biopsy samples obtained before and after cardiopulmonary bypass. The Ca(2+)-independent production of NO found before cardiopulmonary bypass was extremely low (1.5 (0.5) pmol citrulline/mg/min), but was increased after the bypass operation (23.6 (11) pmol/mg/min). Ca(2+)-independent NOS activity was detected in human lung after cardiopulmonary bypass. This finding may provide an important insight into the pathogenesis of the tissue damage and acute phase response observed after such surgery.

References

Aug 1, 1991·European Journal of Clinical Investigation·S Moncada, E A Higgs
Nov 15, 1990·Biochemical and Biophysical Research Communications·R G KilbournR F Lodato
Aug 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·D SalveminiJ R Vane
Jan 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·C ThiemermannJ R Vane
Oct 1, 1993·American Journal of Respiratory Cell and Molecular Biology·L KobzikJ S Stamler
Feb 1, 1993·The Annals of Thoracic Surgery·A MarkewitzB Reichart
Feb 1, 1993·The Annals of Thoracic Surgery·J ButlerS Westaby

❮ Previous
Next ❯

Citations

Apr 1, 1995·Thorax·M Sair, T W Evans
Aug 1, 1997·Journal of Cardiothoracic and Vascular Anesthesia·P S MylesJ Currey
May 1, 1997·Journal of Cardiothoracic and Vascular Anesthesia·G E HillD F Landers
Feb 9, 2002·The Annals of Thoracic Surgery·David P NelsonEllis J Neufeld

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.