Ca(2+) Microdomains in T-Lymphocytes

Frontiers in Oncology
Insa M A Wolf, Andreas H Guse

Abstract

Early Ca(2+) signaling is characterized by occurrence of Ca(2+) microdomains formed by opening of single or clusters of Ca(2+) channels, thereby initiating first signaling and subsequently activating global Ca(2+) signaling mechanisms. However, only few data are available focusing on the first seconds and minutes of Ca(2+) microdomain formation and related signaling pathways in activated T-lymphocytes. In this review, we condense current knowledge on Ca(2+) microdomain formation in T-lymphocytes and early Ca(2+) signaling, function of Ca(2+) microdomains, and microdomain organization. Interestingly, considering the first seconds of T cell activation, a triphasic Ca(2+) signal is becoming apparent: (i) initial Ca(2+) microdomains occurring in the first second of T cell activation, (ii) amplification of Ca(2+) microdomains by recruitment of further channels in the next 5-10 s, and (iii) a transition to global Ca(2+) increase. Apparently, the second messenger nicotinic acid adenine dinucleotide phosphate is the first second messenger involved in initiation of Ca(2+) microdomains. Ryanodine receptors type 1 act as initial Ca(2+) release channels in CD4(+) T-lymphocytes. Regarding the temporal correlation of Ca(2+) microdomains with...Continue Reading

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Citations

Apr 11, 2018·The Journal of Physiology·Andreas H Guse, Björn-Philipp Diercks
Apr 28, 2018·International Journal of Molecular Sciences·Claudia M Tellez FreitasK Scott Weber
Feb 6, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Franz Fenninger, Wilfred A Jefferies
Sep 11, 2019·Cold Spring Harbor Perspectives in Biology·Hwei Ling Ong, Indu Suresh Ambudkar
Dec 20, 2018·Science Signaling·Björn-Philipp DiercksAndreas H Guse
Jan 10, 2019·Nature Reviews. Immunology·Mohamed Trebak, Jean-Pierre Kinet
Oct 27, 2020·Current Opinion in Physiology·Yinhu WangStefan Feske

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Methods Mentioned

BETA
GTPase
nanobiosensors
biosensors

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