Ca(2+)-modulated vision-linked ROS-GC guanylate cyclase transduction machinery.

Molecular and Cellular Biochemistry
Karl-W KochR K Sharma

Abstract

Vertebrate phototransduction depends on the reciprocal relationship between two-second messengers, cyclic GMP and Ca(2+). The concentration of both is reciprocally regulated including the dynamic synthesis of cyclic GMP by a membrane bound guanylate cyclase. Different from hormone receptor guanylate cyclases, the cyclases operating in phototransduction are regulated by the intracellular Ca(2+)-concentration via small Ca(2+)-binding proteins. Based on the site of their expression and their Ca(2+) modulation, this sub-branch of the cyclase family was named sensory guanylate cyclases, of which the retina specific forms are named ROS-GCs (rod outer segment guanylate cyclases). This review focuses on the structure and function of the ROS-GC subfamily present in the mammalian retinal neurons: photoreceptors and inner layers of the retinal neurons. Portions and excerpts of the review are from a previous chapter (Curr Top Biochem Res 6:111-144, 2004).

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Citations

May 11, 2013·FEBS Letters·Karl-Wilhelm Koch
May 9, 2014·Frontiers in Molecular Neuroscience·Anna JankowskaTeresa Duda
Dec 5, 2015·Frontiers in Molecular Neuroscience·Karl-Wilhelm Koch, Daniele Dell'Orco
Jul 30, 2014·Frontiers in Molecular Neuroscience·Rameshwar K Sharma, Teresa Duda
Feb 26, 2014·Cellular and Molecular Life Sciences : CMLS·Daniele Dell'OrcoKarl-Wilhelm Koch
Jan 4, 2012·Journal of Neurochemistry·Ramona FriesKarl-Wilhelm Koch
Oct 4, 2016·Frontiers in Molecular Neuroscience·Rameshwar K SharmaClint L Makino
Feb 11, 2018·Molecular and Cellular Biochemistry·Teresa DudaRameshwar K Sharma
Mar 29, 2014·Frontiers in Molecular Neuroscience·Teresa DudaRameshwar K Sharma
Feb 10, 2016·Frontiers in Molecular Neuroscience·Teresa DudaRameshwar K Sharma
Apr 12, 2014·Frontiers in Molecular Neuroscience·Rameshwar K SharmaTeresa Duda
Feb 19, 2021·Pflügers Archiv : European journal of physiology·Jingjing Zang, Stephan C F Neuhauss
Mar 12, 2013·ACS Chemical Neuroscience·Karl-Wilhelm Koch, Daniele Dell'orco
Jul 11, 2020·Biochimica Et Biophysica Acta. Molecular Cell Research·Giuditta Dal CortivoDaniele Dell'Orco
Oct 25, 2011·Biochimica Et Biophysica Acta·Karl-Wilhelm Koch

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