PMID: 15374673DOI: 10.1016/j.tins.2004.07.010Sep 18, 2004Paper
Ca2+ regulation and gene expression in normal brain aging
Trends in Neurosciences
Emil C ToescuPhilip W Landfield
Abstract
Understanding the cellular mechanisms that characterize the functional changes of the aged brain is an ongoing and formidable challenge for the neuroscience community. Evidence now links changes in Ca(2+) influx and homeostasis with perturbations induced by the aging process in the function of the main intracellular organelles involved in Ca(2+) regulation: the endoplasmic reticulum and mitochondria. New perspectives are also offered by recent gene microarray studies, illustrating the multifactorial nature of the aging process.
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