PMID: 7539842Feb 15, 1995Paper

Ca2+ regulation in the presynaptic terminals of goldfish retinal bipolar cells

The Journal of Physiology
K Kobayashi, M Tachibana

Abstract

1. To investigate regulation of the intracellular free Ca2+ concentration ([Ca2+]i) in presynaptic terminals, the Ca2+ current (ICa) and [Ca2+]i in axon terminals were simultaneously monitored in acutely dissociated retinal bipolar cells under whole-cell voltage clamp. 2. The recovery phase of the Ca2+ transient, which was evoked by activation of ICa, became slower when the Na(+)-Ca2+ exchanger was suppressed by removing extracellular Na+. 3. Inhibition of the plasma membrane Ca2+ pump produced by raising extracellular pH to 8.4 increased the basal [Ca2+]i and caused incomplete recovery from the Ca2+ transient. These effects were not observed in orthovanadate-loaded bipolar cells. 4. The Ca2+ transient was not significantly affected by ryanodine, caffeine, thapsigargin, Ruthenium Red or FCCP. Internal Ca2+ stores may not participate in shaping the Ca2+ transient. 5. The ratio of the peak amplitude of the Ca2+ transient to the total amount of Ca2+ influx became smaller as the size of the Ca2+ influx increased. This action was not affected by blockage of Ca2+ transporters in the plasma membrane, or by reduction of the rate of Ca2+ influx. The peak amplitude of the Ca2+ transient seemed to be determined by Ca2+ buffering substance...Continue Reading

Citations

Nov 1, 1995·Neuropharmacology·E Neher
Mar 3, 2009·Molecular Neurobiology·George Zanazzi, Gary Matthews
Dec 18, 1998·Neuron·H von GersdorffM Tachibana
Dec 1, 1996·Vision Research·C A VandenbrandenH Spekreijse
Aug 5, 2005·Visual Neuroscience·René C RenteríaDavid Krizaj
Apr 1, 1999·Annual Review of Physiology·H von Gersdorff, G Matthews
Mar 15, 2000·Neuroreport·D Wu, P H Zhu
Sep 30, 1998·The European Journal of Neuroscience·P de la VillaA Kaneko
Sep 5, 2002·The Journal of Comparative Neurology·David KrizajDavid R Copenhagen
Jul 18, 2003·Journal of Neurophysiology·Amy B HarkinsAaron P Fox
Aug 18, 2006·Journal of Neurophysiology·Zhen-Yu ZhouRuth Heidelberger
Sep 14, 2012·Journal of Neurophysiology·Qun-Fang WanRuth Heidelberger
Apr 4, 2002·Journal of Neurophysiology·Atsushi DoiNorio Akaike
Oct 8, 1999·Progress in Biophysics and Molecular Biology·M Tachibana

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